DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nr2c1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001016207.1	Gene:	nr2c1 / 548961	XenbaseID:	XB-GENE-484727	Length:	636	Species:	Xenopus tropicalis

Alignment Length:	574	Identity:	136/574 - (23%)
Similarity:	213/574 - (37%)	Gaps:	171/574 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSEG-----SPDM--MDQKYNSVRLSPAASSRILYHVP-------------CKVCRDHSSGKHYG 47
            ||:|     :||.  ::|.:.|....||...:||....             |.||.|.:||:|||
Frog   101 SSQGKVYLTTPDAAGVNQLFISTPDVPAQHIQILSDTQCLDQNLNKQLVELCVVCGDKASGRHYG 165

  Fly    48 IYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGP 112
            ...|:||.||||||||::..|.|:..|.  ||::|.:||:|:.|||::|..:||.:|:||.||.|
Frog   166 AVTCEGCKGFFKRSIRKNLVYTCRGSKD--CVINKHYRNRCQYCRLQRCIALGMKQDSVQCERKP 228

  Fly   113 ------------------------------------RNSTLRRHMAMYK---------------- 125
                                                .|.|.|....:..
Frog   229 IEVSREKSSNCAASTEKIYIRKDLRSPLAATTTFVTENKTSRTTSLLDSGMLVNIQQSGVKNESI 293

  Fly   126 -------DAMMG-----------------AGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAG 166
                   ||..|                 :.|:||...|:.:..:...|    ...:..|.|...
Frog   294 LITPNKVDACQGDLSTLANVVTSLANLNKSKELPQTNTELSIIESLSNG----DSSLSELAQDDQ 354

  Fly   167 HHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNA-------------LATR 218
            .:.....||.   :.|..|:.|....      ||........:...:|             :|.|
Frog   355 SNSEVTRAFD---TLAKALNQSENSA------QGSSECVGSNSNLTDANVEIEGPLLSDAHIAFR 410

  Fly   219 -ALP-PTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYL 281
             .:| |.|..:...:|.|:|:..||.:::|.:|:.:|..|...:.:.|::..|.|.|.|.:||..
Frog   411 LTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPSFQSLGQENSISLVKACWNELFSLGLAQCC 475

  Fly   282 MPMNFAQLL--FVYESENA------NREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL 338
            ..||...:|  ||....|:      :.:.:.:|...:...||..|.:..|::|..||..|:||:|
Frog   476 QVMNVETILAAFVNHLHNSMQHDKLSADKVKLVMDHIFKLQEFCNSMVKLSVDGYEYAYLKAIAL 540

  Fly   339 FRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
            |....|                             ||.....:..:...|.....:|:.:|:|..
Frog   541 FSPDHP-----------------------------GLENVSHIEKLQEKAYMEFQDYVTKTYPED 576

  Fly   404 PMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLI--------SDMYSQ 449
            ..|...||..:..:..:::...|||||...||::.|..:|        ||..||
Frog   577 TYRLSRLLLRLPALRLLNAAITEELFFAGLIGNVQIDSIIPYILRMETSDYNSQ 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/140 (31%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	56/230 (24%)
nr2c1	NP_001016207.1	NR_DBD_TR2_like	147..233	CDD:143525	41/87 (47%)
nr2c1	NP_001016207.1	NR_LBD_TR2_like	401..622	CDD:132750	59/249 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910