Protein Alignment tll and PPARG

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_056953.2
• Gene: PPARG / 5468
• HGNCID: 9236
• Length: 505
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 108/495 - (21%)
• Similarity: 177/495 - (35%)
• Gaps: 145/495 - (29%)

  Fly     9 DMMDQKYNS-VRLSPAA-----------------SSRILYHVPCKVCRDHSSGKHYGIYACDGCA 55
            |:..|:|.| :::.||:                 .|..|..:.|:||.|.:||.|||::||:||.
Human    96 DLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCK 160

  Fly    56 GFFKRSIRRSRQY-VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRR 119
            |||:|:||....| .|...    |.:.|..||:|:.||.:||..|||:.:|::..|.|:
Human   161 GFFRRTIRLKLIYDRCDLN----CRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQ------ 215

  Fly   120 HMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAV 184
                        .|..::.|||..:...|.                            |.||
Human   216 ------------AEKEKLLAEISSDIDQLN----------------------------PESA--- 237

  Fly   185 LDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPP--------LMAAE------HI--- 232
             ||   |.....::..:...|..|.|...|:.|.......|        ||..|      ||
Human   238 -DL---RALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL 298

  Fly   233 ----KETAAEHL----FKNV-------NWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLM 282
                ||.|....    |::|       .:.||:..|..|.:.||:.||:....|.....:|..
Human   299 QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL-- 361

  Fly   283 PMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLC----HLNIDSTEYECLRAISLFRKSP 343
             ||...:|.........||.:..:.:....|.|...:..    .|.:|.::.....|:.:.
Human   362 -MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIIL---- 421

  Fly   344 PSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQ 408
                                     |.:..|||....:..:.::...||...::..||.....|.
Human   422 -------------------------SGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFA 461

  Fly   409 TLLGVVQLMHKVSSFTIEEL-FFRKTIGDITIVRLISDMY 447
            .||..:..:.::.:..::.| ..:||..|:::..|:.::|
Human   462 KLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIY 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/92 (41%)
		NR_LBD	215..436	CDD:416257	46/257 (18%)
PPARG	NP_056953.2	PPARgamma_N	31..108	CDD:289354	4/11 (36%)
		NR_DBD_Ppar	138..221	CDD:143523	37/104 (36%)
		Interaction with FAM120B. /evidence=ECO:0000250	205..280		20/127 (16%)
		NR_LBD_PPAR	237..504	CDD:132730	57/304 (19%)
		Rosiglitazon binding, agonist. /evidence=ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG	314..317		1/2 (50%)
		9aaTAD. /evidence=ECO:0000269|PubMed:30468856	495..503		2/7 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910