Protein Alignment tll and PPARA

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_001001928.1
• Gene: PPARA / 5465
• HGNCID: 9232
• Length: 468
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 122/513 - (23%)
• Similarity: 186/513 - (36%)
• Gaps: 158/513 - (30%)

  Fly     2 QSSEGSPDMMDQKY--------NSV---RLSPAAS-SRILY---------------HVPCKVCRD 39
            :.|.||....:.:|        .||   .||||:| |.:.|               ::.|::|.|
Human    43 EDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGD 107

  Fly    40 HSSGKHYGIYACDGCAGFFKRSIRRSRQY-VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNK 103
            .:||.|||::||:||.|||:|:||....| .|...    |.:.|.:||:|:.||..||..|||:.
Human   108 KASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRS----CKIQKKNRNKCQYCRFHKCLSVGMSH 168

  Fly   104 DAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEIL--------MNTAALTGFPGVPMPMPG 160
            :|::..|.||:                  |..::.||||        ..||.|          ..
Human   169 NAIRFGRMPRS------------------EKAKLKAEILTCEHDIEDSETADL----------KS 205

  Fly   161 LPQRAGHHPAHMAAF-QPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTP 224
            |.:|.  :.|::..| .....|..:|.......|...:|.            |..|.........
Human   206 LAKRI--YEAYLKNFNMNKVKARVILSGKASNNPPFVIHD------------METLCMAEKTLVA 256

  Fly   225 PLMA-------AE----HIKE-TAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAM 277
            .|:|       ||    |..: |:.|.:.:...:.|::..|..|.:.||:.||:....| .|.||
Human   257 KLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYE-AIFAM 320

  Fly   278 AQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCH--------------LNIDST 328
            ...:  ||...:|..|.:        |.:|||.  .:.:....|.              |.:|.:
Human   321 LSSV--MNKDGMLVAYGN--------GFITREF--LKSLRKPFCDIMEPKFDFAMKFNALELDDS 373

  Fly   329 EYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALH 393
            :      ||||              .::|:.....|         |||..|.:..|.......|.
Human   374 D------ISLF--------------VAAIICCGDRP---------GLLNVGHIEKMQEGIVHVLR 409

  Fly   394 NYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEEL----FFRKTIGDITIVRLISDMY 447
            .::|..||.....|..||   |.|..:.....|..    ..:||..|..:..|:.::|
Human   410 LHLQSNHPDDIFLFPKLL---QKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIY 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	39/108 (36%)
		NR_LBD	215..436	CDD:416257	53/250 (21%)
PPARA	NP_001001928.1	NR_DBD_Ppar	101..184	CDD:143523	37/104 (36%)
		NR_LBD_PPAR	201..467	CDD:132730	67/333 (20%)
		Required for heterodimerization with RXRA	304..433		39/173 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910