Protein Alignment tll and PGR

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_000917.3
• Gene: PGR / 5241
• HGNCID: 8910
• Length: 933
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 98/452 - (21%)
• Similarity: 167/452 - (36%)
• Gaps: 75/452 - (16%)

  Fly     5 EGSPDMMDQKYNSVR------LSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIR 63
            ||.|.:.....|.:|      .||..|...|....|.:|.|.:||.|||:..|..|..||||::.
Human   532 EGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAME 596

  Fly    64 RSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAM 128
            ....|:|..:..  |:|||..|..|.|||||||.:.||....            |:.....|..:
Human   597 GQHNYLCAGRND--CIVDKIRRKNCPACRLRKCCQAGMVLGG------------RKFKKFNKVRV 647

  Fly   129 MGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVP 193
            :.|.:...:|..:           |||.....|.||....|.......||     :::|.:...|
Human   648 VRALDAVALPQPV-----------GVPNESQALSQRFTFSPGQDIQLIPP-----LINLLMSIEP 696

  Fly   194 HHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPM 258
             ..::.||......|:   ::|.|             .:.:.....|...|.|.||:..|..|.:
Human   697 -DVIYAGHDNTKPDTS---SSLLT-------------SLNQLGERQLLSVVKWSKSLPGFRNLHI 744

  Fly   259 PDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQ------EVL 317
            .||:.|::.||....:..:..........|:|:.......|.:.|    :|...:.      ::.
Human   745 DDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRM----KESSFYSLCLTMWQIP 805

  Fly   318 NQLCHLNIDSTEYECLRAISLFRKSP----PSASSTEDLANS---SILTGSGSPNSSASAESRGL 375
            .:...|.:...|:.|::.:.|....|    .|.:..|::.:|   .::...|.......:.|:..
Human   806 QEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRF 870

  Fly   376 LESGKVAAMHNDARSALHNYIQRT---HPSQPMRFQTLLG--VVQLMHKVSSFTIEELFFRK 432
            .:..|:....:|....||.|...|   ..:..:.|..::.  :...:.|:.:..::.|.|.|
Human   871 YQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	33/91 (36%)
		NR_LBD	215..436	CDD:416257	40/236 (17%)
PGR	NP_000917.3	Modulating, Pro-Rich	1..566		9/33 (27%)
		Prog_receptor	1..564	CDD:280346	9/31 (29%)
		AF3, mediates transcriptional activation (in isoform B). /evidence=ECO:0000269|PubMed:11546784	1..164
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..157
		LXXL motif 1. /evidence=ECO:0000305|PubMed:11546784	55..59
		LXXL motif 2. /evidence=ECO:0000305|PubMed:11546784	115..119
		Mediates transcriptional transrepression (in isoform A). /evidence=ECO:0000269|PubMed:9407067	165..305
		Nuclear localization signal. /evidence=ECO:0000255	183..187
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..351
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..452
		AF1, mediates transcriptional activation. /evidence=ECO:0000269|PubMed:1587864	456..546		4/13 (31%)
		NR_DBD_GR_PR	563..640	CDD:143546	32/90 (36%)
		NR_LBD_PR	686..933	CDD:132759	46/273 (17%)
		AF2, mediates transcriptional activation. /evidence=ECO:0000269|PubMed:1587864	687..933		45/267 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910