Protein Alignment tll and NR4A2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: XP_005246678.1
• Gene: NR4A2 / 4929
• HGNCID: 7981
• Length: 609
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 94/424 - (22%)
• Similarity: 164/424 - (38%)
• Gaps: 134/424 - (31%)

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|:::.:|||:..|:||.|||||:::::.:|||.:.|.  |.|||..||:|:.||.:||..
Human   274 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKN--CPVDKRRRNRCQYCRFQKCLA 336

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMG-AGEMPQIPAEILMNTAALTGFPGVPMPMPGLP 162
            |||.|:.|:                 .|::.| .|.:|..|..           |..|.|
Human   337 VGMVKEVVR-----------------TDSLKGRRGRLPSKPKS-----------PQEPSP----- 368

  Fly   163 QRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLM 227
                          |.|..:.:..|....|..:|.              |.:|........|...
Human   369 --------------PSPPVSLISALVRAHVDSNPA--------------MTSLDYSRFQANPDYQ 405

  Fly   228 AA----EHIKE-----TAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMP 283
            .:    :||::     |.:..:.:  .|.:.:..|.:||..||.||.|.::.|.|:|.:|....|
Human   406 MSGDDTQHIQQFYDLLTGSMEIIR--GWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNP 468

  Fly   284 MNFAQLLFVYESENANREIMGMVTREVHAFQ-------------EVLNQLCHLNIDSTEYECLRA 335
            :. .:|:|          ..|:|   :|..|             |..:.|.::|||.:.:.|:.|
Human   469 VE-GKLIF----------CNGVV---LHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAA 519

  Fly   336 ISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTH 400
            :::.                              .|..||.|..:|..:.|...:.|.:::...:
Human   520 LAMV------------------------------TERHGLKEPKRVEELQNKIVNCLKDHVTFNN 554

  Fly   401 P--SQPMRFQTLLGVVQLMHKVSSFTIEELFFRK 432
            .  ::|.....|||.:..:..:.:..::.:|:.|
Human   555 GGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLK 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	35/82 (43%)
		NR_LBD	215..436	CDD:416257	45/242 (19%)
NR4A2	XP_005246678.1	NR_DBD_NGFI-B	272..346	CDD:143527	35/90 (39%)
		NR_LBD_Nurr1	372..609	CDD:132756	49/277 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910