DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nr2e3

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001007369.1	Gene:	nr2e3 / 492496	ZFINID:	ZDB-GENE-041114-63	Length:	419	Species:	Danio rerio

Alignment Length:	463	Identity:	152/463 - (32%)
Similarity:	228/463 - (49%)	Gaps:	79/463 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQY 68
            |..:.|..|.|      |||....:...:.||||.|.|||||||||||:||:||||||:||...|
Zfish    15 SNSTDDSQDGK------SPAPGKVLNTGLLCKVCSDTSSGKHYGIYACNGCSGFFKRSVRRRLIY 73

  Fly    69 VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTL-----------RRHMA 122
            .|:: ..|:|.|||.|||||:||||:||.:.||||||||:||.||::..           :.|:|
Zfish    74 RCQA-GTGMCPVDKAHRNQCQACRLKKCLQAGMNKDAVQNERQPRSTAQVRLDALDVDKDKEHLA 137

  Fly   123 MYKDAMMGAG----EMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAA 183
            ...:....:.    ..|.:.:.|..:.::..|......|      :.||.  .||:.....:.|.
Zfish   138 TTLEPTSSSTCSVISRPLLGSSISSSISSTDGSQHSNSP------KNGHR--FMASLMTAETCAK 194

  Fly   184 V----LDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNV 244
            :    :|.::....:.|...      ||  .|.:||    .|...|    |.:.||:|..||.:|
Zfish   195 LEPEDVDENIDVTSNEPERS------SP--MYGSAL----YPSREP----ESVYETSARLLFMSV 243

  Fly   245 NWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTRE 309
            .|.|::..|:.||..||::||||:|.|.|:|...|:.:|::...||.:.:.....:........:
Zfish   244 KWAKNLPVFSHLPFRDQVILLEEAWSELFLLCAIQWSLPLDNCPLLSLPDLSPTGQGKGSPSASD 308

  Fly   310 VHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRG 374
            |...|||.::...|.:|.||:.||:||.||:                             .|:||
Zfish   309 VRVLQEVFSRFKPLQVDPTEFACLKAIVLFK-----------------------------PETRG 344

  Fly   375 LLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITI 439
            |.:..:|..:.:.::..|..:|...:|||..||..||.::..:|.|||..||.|||::|||:..:
Zfish   345 LKDPEQVENLQDQSQVLLAQHIHTLYPSQVARFGRLLLLLPSLHFVSSERIEHLFFQRTIGNTPM 409

  Fly   440 VRLISDMY 447
            .:|:.||:
Zfish   410 EKLLCDMF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	56/91 (62%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	68/220 (31%)
nr2e3	NP_001007369.1	NR_DBD_PNR	31..122	CDD:143528	56/91 (62%)
nr2e3	NP_001007369.1	NR_LBD_Tlx_PNR_like	201..406	CDD:132748	74/249 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920