DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nr2e1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001003608.1	Gene:	nr2e1 / 445214	ZFINID:	ZDB-GENE-040801-127	Length:	396	Species:	Danio rerio

Alignment Length:	457	Identity:	186/457 - (40%)
Similarity:	258/457 - (56%)	Gaps:	74/457 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQ 67
            |:.|..|:::.|          ||||| .:|||||.|.|||||||:||||||:|||||||||:|.
Zfish     7 STSGCLDILNVK----------SSRIL-DIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRT 60

  Fly    68 YVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAG 132
            |||||..||.|.||||||||||||||:||.||.|||||||||||||.||:|:.:|:|   ..|..
Zfish    61 YVCKSGTQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALY---FRGHK 122

  Fly   133 EMPQIPAEILMNTAALTGFPGVPMPMPGL---PQRAGHHPAHMAAFQPPPSAAAVLDLS--VPRV 192
            |:          ..:.|.||...:|.|..   ..:...|...:......|...|::.|:  .|:.
Zfish   123 EV----------NGSSTHFPSTSIPGPPFFTTVTQLEPHNLELNTVTSTPERQAIVGLAQPTPKY 177

  Fly   193 PHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELP 257
            ||.         .|.|..|:..:||            |.:.|:||..||.::.|.|||.||:.||
Zfish   178 PHE---------VSGTPMYLYEVAT------------ESVCESAARLLFMSIKWAKSVPAFSTLP 221

  Fly   258 MPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFV--YESENANREIMGMVTREVHAFQEVLNQL 320
            :||||:|||::|:|.|:|.:||:.:|::.:.||.|  ..:||.:.:.:..:..|:.|.|||:.:.
Zfish   222 LPDQLILLEDAWRELFVLGIAQWAIPVDSSTLLAVSGMNTENTDSQRLNKIISEIQALQEVVTRF 286

  Fly   321 CHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMH 385
            ..|.:|:||:.||:.|..|:..|               |.|||       |.|....:..:||:.
Zfish   287 RQLRLDATEFACLKCIVTFKAVP---------------THSGS-------ELRSFRNASAIAALQ 329

  Fly   386 NDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQR 450
            ::|:..|::||...:|:||.||..||.::..:..|...||||:||:||||::.|.||:||||...
Zfish   330 DEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSVGPSTIEEVFFKKTIGNVPITRLLSDMYKSS 394

  Fly   451 KI 452
            .|
Zfish   395 DI 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	74/91 (81%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	78/222 (35%)
nr2e1	NP_001003608.1	NR_DBD_TLX	19..110	CDD:143537	74/91 (81%)
nr2e1	NP_001003608.1	NR_LBD_Tlx_PNR_like	165..380	CDD:132748	86/257 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587074
Domainoid	1	1.000	134	1.000	Domainoid score	I4993
eggNOG	1	0.900	-	-		E33208_3BC6Q
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45707
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	1	1.000	-	-		oto41385
orthoMCL	1	0.900	-	-		OOG6_108295
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10591
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.750