Protein Alignment tll and NR3C2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: XP_011530277.1
• Gene: NR3C2 / 4306
• HGNCID: 7979
• Length: 988
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 115/517 - (22%)
• Similarity: 180/517 - (34%)
• Gaps: 168/517 - (32%)

  Fly     4 SEGSP-------DMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRS 61
            |:|.|       ::......||....:..|:|     |.||.|.:||.|||:..|..|..||||:
Human   571 SDGYPVLEYIPENVSSSTLRSVSTGSSRPSKI-----CLVCGDEASGCHYGVVTCGSCKVFFKRA 630

  Fly    62 IRR----SRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMA 122
            :..    ...|:|..:..  |::||..|..|.||||:||.:.|||..|      .::..|.:...
Human   631 VEGKCSWQHNYLCAGRND--CIIDKIRRKNCPACRLQKCLQAGMNLGA------RKSKKLGKLKG 687

  Fly   123 MYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDL 187
            :::       |.||...            |..|.|.|..|:....:.|  .|.:|..:.|.|..|
Human   688 IHE-------EQPQQQQ------------PPPPPPPPQSPEEGTTYIA--PAKEPSVNTALVPQL 731

  Fly   188 SVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHI------------KETAAEHL 240
            |.                          .:|||.|: |:|..|:|            |...||:|
Human   732 ST--------------------------ISRALTPS-PVMVLENIEPEIVYAGYDSSKPDTAENL 769

  Fly   241 FKNVN------------WIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLF-- 291
            ...:|            |.|.:..|..||:.||:.|::.||......|::........:|.|:
Human   770 LSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFA 834

  Fly   292 ---VYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLA 353
               |:..|..::..|..:.:.:|   ::..|...|.:...||..::.:.|.
Human   835 PDLVFNEEKMHQSAMYELCQGMH---QISLQFVRLQLTFEEYTIMKVLLLL-------------- 882

  Fly   354 NSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTH------PSQP----MRFQ 408
              |.:...|..:.:|..|.|                   .|||:...      |:..    .||.
Human   883 --STIPKDGLKSQAAFEEMR-------------------TNYIKELRKMVTKCPNNSGQSWQRFY 926

  Fly   409 TLLGVVQLMHKVSSFTIEELFFR-------KTIGDITIVRLISD------------MYSQRK 451
            .|..::..||.:.|..:|..|:.       |......:|.:|||            :|..||
Human   927 QLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	34/95 (36%)
		NR_LBD	215..436	CDD:416257	53/266 (20%)
NR3C2	XP_011530277.1	NR_DBD_GR_PR	599..677	CDD:143546	34/90 (38%)
		NR_LBD_MR	741..988	CDD:132760	54/285 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910