DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and esr1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_988866.1	Gene:	esr1 / 394461	XenbaseID:	XB-GENE-482193	Length:	543	Species:	Xenopus tropicalis

Alignment Length:	452	Identity:	111/452 - (24%)
Similarity:	185/452 - (40%)	Gaps:	123/452 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|::||.|||:::|:||..||||||:....|:|.:..|  |.:||..|..|:|||||||:|
Frog   137 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQ--CTIDKNRRKSCQACRLRKCYE 199

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQ----IPAEILMNTAALTGFPGVPMPMP 159
            |||.|..::.:|  |...:.:|....:       |..|    .|:||  .|.::...|.|
Frog   200 VGMMKGGIRKDR--RGGRMLKHKRQKE-------EQEQKNDVTPSEI--RTTSIWVNPSV----- 248

  Fly   160 GLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTP 224
                             .....:.||.|:..::               .:|.|.|        .|
Frog   249 -----------------KSMKLSPVLSLTAEQL---------------ISALMEA--------EP 273

  Fly   225 PLMAAEH--------------IKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFIL 275
            |::.:||              :...|.:.|...:||.|.|..|.:|.:.||:.|||.:|.|..::
Frog   274 PIVYSEHDSTKPLSEASMMTLLTNLADKELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMV 338

  Fly   276 AM----AQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLC-------HLNIDSTE 329
            .:    .::...::||..|.:  ..|..|.:.|:|        |:.:.|.       .:.:...|
Frog   339 GLIWRSVEHPGKLSFAPNLLL--DRNQGRCVEGLV--------EIFDMLVTTATRFRMMRLRGEE 393

  Fly   330 YECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLE--SGKV--AAMHNDARS 390
            :.||::|.|.              ||.:.|...|  :..|.|...|:.  ..|:  ..:|..|:|
Frog   394 FICLKSIILL--------------NSGVYTFLSS--TLESLEDTDLIHIILDKIIDTLVHFMAKS 442

  Fly   391 ALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI 452
            .|.  :|:    |..|...||.::..:..:|:..:|.|:..|....:.:..|:.:|....::
Frog   443 GLS--LQQ----QQRRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRM 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	40/82 (49%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	54/249 (22%)
esr1	NP_988866.1	Oest_recep	<40..133	CDD:280344
		NR_DBD_ER	132..213	CDD:143545	39/79 (49%)
		NR_LBD_ER	259..496	CDD:132747	60/291 (21%)
		ESR1_C	509..543	CDD:289512
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910