DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and esr2

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001035101.1	Gene:	esr2 / 394460	XenbaseID:	XB-GENE-486256	Length:	548	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	100/381 - (26%)
Similarity:	147/381 - (38%)	Gaps:	74/381 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVV 80
            |:|..:|.:.....:   |.||.|::||.|||:::|:||..||||||:....|:|.:..|  |.:
Frog   152 NNVGSNPGSKRDTHF---CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQ--CTI 211

  Fly    81 DKTHRNQCRACRLRKCFEVGMNKDAVQHER-GPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMN 144
            ||..|..|:||||||||||||.|...:.|| |.|....|||.   .|.|....:..::...|
Frog   212 DKNRRKSCQACRLRKCFEVGMMKCGTRRERCGYRIVRHRRHS---DDQMHCLAKNKKLTDNI--- 270

  Fly   145 TAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTA 209
                              ||.....|  ::..|......:.|...|.|
Frog   271 ------------------QRVKEISA--SSLGPEQFVLIISDAEPPNV----------------- 298

  Fly   210 AYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFI 274
                .|..|...|.........:.:.|.:.|...:.|.|.:..|.||.:.||:.|||..|.|  |
Frog   299 ----MLMNRLCKPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLYDQVRLLESCWLE--I 357

  Fly   275 LAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVL---NQLCHLNIDSTEYECLRAI 336
            |.|......::....|........:|:....|...:..|..:|   ::|..|.:...|:.||:.:
Frog   358 LMMGLMWRSIDHPGKLLFAPDLTLDRDEGKCVEGILEIFDMLLATTSRLRELKLQHREFLCLKVM 422

  Fly   337 SLFRKSPPSASSTEDLANSS----------------ILTGSGSPNSSASAESRGLL 376
            .|........:|:|:.:.||                ::..||.|....|.....||
Frog   423 ILLNSHVFPLTSSEEESESSRKLHHPLNTVTDALVWVIAKSGIPFRQQSTRLANLL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	43/92 (47%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	41/181 (23%)
esr2	NP_001035101.1	ERbeta_N	39..139	CDD:289279
		NR_DBD_ER	162..243	CDD:143545	41/85 (48%)
		NR_LBD_ER	281..517	CDD:132747	45/221 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910