DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Rxrb

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006256022.1	Gene:	Rxrb / 361801	RGDID:	3611	Length:	689	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	115/438 - (26%)
Similarity:	177/438 - (40%)	Gaps:	119/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRN 86
            |.|..|:     |.:|.|.|||||||:|:|:||.|||||:||:...|.|:..|.  |.|||..||
  Rat   350 PGAGKRL-----CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKD--CTVDKRQRN 407

  Fly    87 QCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDA-MMGAGEMPQ-------IPAEILM 143
            :|:.||.:||...||.::|||.|         |.....||. ..|||..|:       :.||:.:
  Rat   408 RCQYCRYQKCLATGMKREAVQEE---------RQRGKDKDGDGDGAGGAPEEMPVDRILEAELAV 463

  Fly   144 NTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPT 208
            ...:..|..|     ||....:|..                        |:.||
  Rat   464 EQKSDQGVEG-----PGGTGGSGSS------------------------PNDPV----------- 488

  Fly   209 AAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFF 273
                                 .:|.:.|.:.||..|.|.|.:..|:.||:.||::||...|.|..
  Rat   489 ---------------------TNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELL 532

  Fly   274 ILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREV-HAFQEVLNQLCHLNIDSTEYECL 333
            |.:.:...:.:.    .|..|.|:.:...:..:..:..|.: ....|:::::..:.:|.||..||
  Rat   533 IASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCL 597

  Fly   334 RAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQR 398
            |||.||                             :.:::||...|:|..:.....::|..|.::
  Rat   598 RAIILF-----------------------------NPDAKGLSNPGEVEILREKVYASLETYCKQ 633

  Fly   399 THPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            .:|.|..||..||..:..:..:....:|.|||.|.|||..|...:.:|
  Rat   634 KYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEM 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/91 (46%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	50/225 (22%)
Rxrb	XP_006256022.1	NR_DBD_RXR	356..431	CDD:143514	41/90 (46%)
Rxrb	XP_006256022.1	NR_LBD_RXR_like	450..667	CDD:132741	58/306 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910