DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and esr2b

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_005157028.1	Gene:	esr2b / 317733	ZFINID:	ZDB-GENE-030116-1	Length:	600	Species:	Danio rerio

Alignment Length:	455	Identity:	119/455 - (26%)
Similarity:	182/455 - (40%)	Gaps:	125/455 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|::||.|||:::|:||..||||||:....|:|.:..|  |.:||:.|..|:|||||||:|
Zfish   165 CAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQ--CTIDKSRRKSCQACRLRKCYE 227

  Fly    99 VGMNKDAVQ------------------HERGP--RNST-----LR----RHMAMYKDAMMGAGEM 134
            |||.|..:|                  |.|.|  |:|:     ||    :|:           |.
Zfish   228 VGMMKCGMQLTLRFCVRRERCSYRGARHRRNPQIRDSSGGVVGLRGQSQQHL-----------EF 281

  Fly   135 PQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRV-PHHPVH 198
            |..|::.|        ||.           .|........:.|....:.:|:...|:: ...||.
Zfish   282 PLSPSQHL--------FPS-----------GGRAEGRGLNYSPEQLVSCILEAEPPQIYLREPVK 327

  Fly   199 QGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLL 263
            :.:     ..|:.|.:|.:                 .|.:.|...::|.|.:..|.||.:.||:.
Zfish   328 KPY-----TEASMMMSLTS-----------------LADKELVLMISWAKKIPGFVELTLSDQVH 370

  Fly   264 LLEESWKEFFILAMAQYLMPMNFAQLLFV----YESENAN-----REIMGMVTREVHAFQEVLNQ 319
            |||..|.:..:|.: .:....:..:|:|.    ...|..|     .||..|:......|:|
Zfish   371 LLECCWLDILMLGL-MWRSVDHPGKLIFTPDLKLNREEGNCVEGIMEIFDMLLATTSRFRE---- 430

  Fly   320 LCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAM 384
               |.:...||.||:|:.|...:           |.|.|     |.:....|||     |||..:
Zfish   431 ---LKLQREEYVCLKAMILLNSN-----------NCSSL-----PQTPEDVESR-----GKVLNL 471

  Fly   385 HNDARSALHNYIQRTHPS---QPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            .:....||...|.||..|   |.:|...||.::..:..:|:..||.|...|....:.:..|:.:|
Zfish   472 LDSVTDALVWIISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSNMKRKNVVLLYDLLLEM 536

Fly 447 446
Zfish 537 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/107 (41%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	56/232 (24%)
esr2b	XP_005157028.1	ERbeta_N	31..132	CDD:289279
		NR_DBD_ER	160..249	CDD:143545	39/85 (46%)
		NR_LBD_ER	304..527	CDD:132747	63/273 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910