Protein Alignment tll and HNF4A

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: XP_005260464.1
• Gene: HNF4A / 3172
• HGNCID: 5024
• Length: 513
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 113/433 - (26%)
• Similarity: 173/433 - (39%)
• Gaps: 139/433 - (32%)

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.:|.|.::|||||..:||||.|||:||:|::..|.|:..:|  |||||..|||||.|||:|||.
Human    99 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQ--CVVDKDKRNQCRYCRLKKCFR 161

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQI----PAEILMN--TAALTGFPGVPMP 157
            .||.|:|||:|| .|.||.|   :.|:|:     .:|.|    .||:|..  |:.::|..|
Human   162 AGMKKEAVQNER-DRISTRR---SSYEDS-----SLPSINALLQAEVLSRQITSPVSGING---- 213

  Fly   158 MPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPP 222
                                        |:...::
Human   214 ----------------------------DIRAKKI------------------------------ 220

  Fly   223 TPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQ-------- 279
                .:...:.|:..|.|...|.|.|.:.||.|||:.||:.||.....|..:|...:
Human   221 ----ASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV 281

  Fly   280 ------YLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISL 338
                  |::|.:..:|      ...:|..:.::...|..|||       |.||..||..|:||..
Human   282 LLLGNDYIVPRHCPEL------AEMSRVSIRILDELVLPFQE-------LQIDDNEYAYLKAIIF 333

  Fly   339 FRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
            |                             ..:::||.:.||:..:.:..:.:|.:||.......
Human   334 F-----------------------------DPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDS 369

  Fly   404 PMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            ..||..||.::..:..::...||::.|.|..|...|..|:.:|
Human   370 RGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	47/82 (57%)
		NR_LBD	215..436	CDD:416257	49/234 (21%)
HNF4A	XP_005260464.1	NR_DBD_HNF4A	99..174	CDD:143518	45/77 (58%)
		NR_LBD_HNF4_like	190..412	CDD:132729	60/329 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910