DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Rorb

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001257887.1	Gene:	Rorb / 309288	RGDID:	1306778	Length:	459	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	115/491 - (23%)
Similarity:	205/491 - (41%)	Gaps:	123/491 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKC 96
            :|||:|.|.|||.|||:..|:||.|||:||.:.:..|.|..|:.  |::|:|:||:|:.|||:||
  Rat     8 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRN--CLIDRTNRNRCQHCRLQKC 70

  Fly    97 FEVGMNKDAV------QHERGPRNSTLRRH-MAMYKDAMMGAGEMPQIPAEI--------LMNTA 146
            ..:||::|||      :.:|....:.:::| ..:.:.....:||...: |.:        |.|..
  Rat    71 LALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEAL-ARVYSSSISNGLSNLN 134

  Fly   147 ALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVH------------Q 199
            ..||.......:..||:..|::  ::.:.||.|..:.:....:.::...|::            .
  Rat   135 TETGGTYANGHVIDLPKSEGYY--NIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSS 197

  Fly   200 GHHGFFSP--TAAYMNALATR-----------ALPPTPPLMAAEHIKETAAEHLFKN-------- 243
            .::|..:|  |.:.::.:|..           .:.....|....|..|....:..|:
  Rat   198 FNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQC 262

  Fly   244 -----------VNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESEN 297
                       |.:.|.:..|.||...||:|||:....|..::.|.:...|:|...|   :|.:.
  Rat   263 AIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVL---FEGKY 324

  Fly   298 ANREIMGMVTREVHAFQEVLNQ-------LCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANS 355
            .     ||...:.....:::|:       ||.|.:  ||.|    |:||              :|
  Rat   325 G-----GMQMFKALGSDDLVNEAFDFAKNLCSLQL--TEEE----IALF--------------SS 364

  Fly   356 SILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKV 420
            ::|         .|.:...|||..||..:......||.:.||:.|    :..:||   .:|:.|:
  Rat   365 AVL---------ISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNH----LDDETL---AKLIAKI 413

  Fly   421 SSFTI------EEL-FFRKTIGDITIVRLISDMYSQ 449
            .:.|.      |:| .|:::..|| :..|...:|.:
  Rat   414 PTITAVCNLHGEKLQVFKQSHPDI-VNTLFPPLYKE 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	39/90 (43%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	54/264 (20%)
Rorb	NP_001257887.1	NR_DBD_ROR	3..97	CDD:143526	39/90 (43%)
Rorb	NP_001257887.1	NR_LBD_ROR_like	210..450	CDD:132737	58/284 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910