DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and rxrbb

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_571313.1	Gene:	rxrbb / 30486	ZFINID:	ZDB-GENE-990415-242	Length:	422	Species:	Danio rerio

Alignment Length:	461	Identity:	121/461 - (26%)
Similarity:	189/461 - (40%)	Gaps:	132/461 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRS 65
            ::|..||..|:.||    |:             |.:|.|.|||||||:|:|:||.|||||::|:.
Zfish    74 LKSVSGSGPMLSQK----RM-------------CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKD 121

  Fly    66 RQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMG 130
            ..|.|:..|:  |:|||..||:|:.||.:||..:||.::|||.|| .:|.
Zfish   122 LSYTCRDNKE--CLVDKRQRNRCQYCRYQKCLAMGMKREAVQEER-QKNK--------------- 168

  Fly   131 AGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHH 195
                                            :|.|.:....:|.:..| ...:|:... .|.|.
Zfish   169 --------------------------------ERDGDYECSSSANEEMP-VEKILEAET-AVEHR 199

  Fly   196 PVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPD 260
                        |..:.:|..:    |..|:   .:|.:.|.:.||..|.|.|.|..|:::|:.|
Zfish   200 ------------TDLHSDATGS----PNDPV---TNICQAADKQLFTLVEWAKRVPHFSDVPLDD 245

  Fly   261 QLLLLEESWKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTRE-VHA------FQ 314
            |::||...|.|..|.|.:...:.:.    .|..|.|.:....|..:.....|| .|:      |.
Zfish   246 QVILLRAGWNELLIAAFSHRSISVKDEILLATGLHVPKESTHNLGVEAFFDRESSHSAEVGALFD 310

  Fly   315 EVLNQL-C---HLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGL 375
            .||.:| |   .:.:|.||..|||||.||                             :.:::||
Zfish   311 RVLTELVCKMRDMQMDKTELGCLRAIVLF-----------------------------NPDAKGL 346

  Fly   376 LESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIV 440
            ..|.:|..:.....::|.:|.::.:|.|..||..||..:..:..:....:|.|||.|.||:..|.
Zfish   347 TSSSEVELLREKVYASLESYCKQKYPDQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGNTPID 411

  Fly   441 RLISDM 446
            ..:.:|
Zfish   412 TFLMEM 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/91 (46%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	60/235 (26%)
rxrbb	NP_571313.1	Modulating. /evidence=ECO:0000250	1..89		6/18 (33%)
		Nuc_recep-AF1	<21..77	CDD:288658	0/2 (0%)
		NR_DBD_RXR	89..164	CDD:143514	39/89 (44%)
		Hinge. /evidence=ECO:0000250	156..178		8/69 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..182		7/68 (10%)
		NR_LBD_RXR_like	183..403	CDD:132741	64/269 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910