DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and rxrga

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_571292.3	Gene:	rxrga / 30464	ZFINID:	ZDB-GENE-980526-36	Length:	441	Species:	Danio rerio

Alignment Length:	430	Identity:	115/430 - (26%)
Similarity:	184/430 - (42%)	Gaps:	108/430 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHR 85
            ||.:.|:   |: |.:|.|.|||||||:|:|:||.|||||:||:...|.|:..|.  |.:||..|
Zfish   108 SPGSLSK---HI-CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYTCRDNKD--CQIDKRQR 166

  Fly    86 NQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTG 150
            |:|:.||.:||..:||.::|||.||    ...|.......|:.....|  ::|.|.:::
Zfish   167 NRCQYCRYQKCLAMGMKREAVQEER----QRGRERSDNEVDSSSSFNE--EMPVEKILD------ 219

  Fly   151 FPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNAL 215
                               |.:|.   .|...|.::.|:....:.||
Zfish   220 -------------------AELAV---EPKTEAYMESSMSNSTNDPV------------------ 244

  Fly   216 ATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQY 280
                          .:|.:.|.:.||..|.|.|.:..|::||:.||::||...|.|..|.:.:..
Zfish   245 --------------TNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHR 295

  Fly   281 LMPMN----FAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRK 341
            .:.:.    .|..|.|:.| :|:...:|.:...|  ..|:::::..:.:|.||..|||||.||
Zfish   296 SVTVKDGILLATGLHVHRS-SAHSAGVGSIFDRV--LTELVSKMREMQMDKTELGCLRAIVLF-- 355

  Fly   342 SPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMR 406
                                       :.:::||....:|.|:.....::|..|.:..:|.||.|
Zfish   356 ---------------------------NPDAKGLSNPSEVEALREKVYASLEGYTKHNYPDQPGR 393

  Fly   407 FQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            |..||..:..:..:....:|.|||.|.|||..|...:.:|
Zfish   394 FAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEM 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	43/91 (47%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	54/224 (24%)
rxrga	NP_571292.3	Modulating. /evidence=ECO:0000250	1..116		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..37
		Nuc_recep-AF1	<40..111	CDD:288658	2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..94
		NR_DBD_RXR	115..191	CDD:143514	40/78 (51%)
		Hinge	183..206		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..210		5/25 (20%)
		NR_LBD_RXR_like	211..419	CDD:132741	61/299 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910