DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nr2f1a

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_571255.1	Gene:	nr2f1a / 30418	ZFINID:	ZDB-GENE-980526-115	Length:	411	Species:	Danio rerio

Alignment Length:	420	Identity:	130/420 - (30%)
Similarity:	202/420 - (48%)	Gaps:	100/420 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRK 95
            |:.|.||.|.|||||||.:.|:||..|||||:||:..|.|::.:.  |.:|:.|||||:.|||:|
Zfish    73 HIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRN--CPIDQHHRNQCQYCRLKK 135

  Fly    96 CFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPG 160
            |.:|||.::|||.                       |.||  |.:......|||.  |.|:
Zfish   136 CLKVGMRREAVQR-----------------------GRMP--PTQPNPGQYALTN--GDPL---- 169

  Fly   161 LPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPP 225
                .||  .:::.:         :.|.:...|:            ||:.|    .::.:.|. .
Zfish   170 ----NGH--CYLSGY---------ISLLLRAEPY------------PTSRY----GSQCMQPN-N 202

  Fly   226 LMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLL 290
            :|..|:|.|.||..||..|.|.:::..|.:|.:.||:.||..:|.|.|:|..||..||::.|.||
Zfish   203 IMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLL 267

  Fly   291 F---VYESE-NANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTED 351
            .   ::.|. :|:|.:..|  ..:..|||.:.:|..|::||.||.|::||.||
Zfish   268 AAAGLHASPMSADRVVAFM--DHIRIFQEQVEKLKALHVDSAEYSCIKAIVLF------------ 318

  Fly   352 LANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQL 416
                             ::::.||.::..:.::...::.||..|::..:|:||.||..||..:..
Zfish   319 -----------------TSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPS 366

  Fly   417 MHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            :..|||..||:|||.:.:|...|..||.||
Zfish   367 LRTVSSSVIEQLFFVRLVGKTPIETLIRDM 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/85 (49%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	66/224 (29%)
nr2f1a	NP_571255.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		gliding_GltJ	<11..>59	CDD:411345
		NR_DBD_COUP_TF	76..148	CDD:143516	40/73 (55%)
		NR_LBD_COUP-TF	174..409	CDD:132746	77/280 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910