DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Esrra

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001008511.2	Gene:	Esrra / 293701	RGDID:	1583866	Length:	422	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	108/419 - (25%)
Similarity:	162/419 - (38%)	Gaps:	120/419 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ILYHVP---CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCR 89
            :|..:|   |.||.|.:||.|||:.:|:.|..||||:|:.|.:|.|.:..:  |.:.|..|..|:
  Rat    70 VLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNE--CEITKRRRKACQ 132

  Fly    90 ACRLRKCFEVGMNKDAVQHE--RGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFP 152
            |||..||..|||.|:.|:.:  ||.|....||               |::.
  Rat   133 ACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRR---------------PEVD-------------- 168

  Fly   153 GVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALAT 217
              |:|.|| |..||            |.|.|    ..||                ..|.:|||.:
  Rat   169 --PLPFPG-PFPAG------------PLAVA----GGPR----------------KTAPVNALVS 198

  Fly   218 RALPPTP--------PLMAAEHIKETAA------EHLFKNVNWIKSVRAFTELPMPDQLLLLEES 268
            ..|...|        |.....|:...|.      ..:...::|.||:..|:.|.:.||:.:|:..
  Rat   199 HLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSV 263

  Fly   269 WKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTE 329
            |.|..:|.:||..:|:.    ||:.| |.:.|.|....:|.:..   |..:::.:|..|.::..|
  Rat   264 WMEVLVLGVAQRSLPLQDELAFAEDL-VLDEEGARAAGLGDLGA---ALLQLVRRLQALRLEREE 324

  Fly   330 YECLRAISLFRKSP---PSASSTEDL---ANSSIL---TGSGSPNSSASAESRGLL--------- 376
            |..|:|::|.....   ..|.:.|.|   .:.::|   .|...|...|.....|.|
  Rat   325 YVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQ 389

  Fly   377 ESGKVAAMHNDARSALHNYIQRTHPSQPM 405
            .:|||.|         |.|..:.....||
  Rat   390 TAGKVLA---------HFYGVKLEGKVPM 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/93 (41%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	52/227 (23%)
Esrra	NP_001008511.2	Repressor domain. /evidence=ECO:0000250	1..76		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		NR_DBD_ERR	73..168	CDD:143544	40/111 (36%)
		NR_LBD_ERR	196..419	CDD:132744	52/227 (23%)
		AF-2 domain. /evidence=ECO:0000250	402..422		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910