DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Esrrg

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_036065.1	Gene:	Esrrg / 26381	MGIID:	1347056	Length:	458	Species:	Mus musculus

Alignment Length:	422	Identity:	95/422 - (22%)
Similarity:	168/422 - (39%)	Gaps:	105/422 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|.:||.|||:.:|:.|..||||:|:.:.:|.|.:..:  |.:.|..|..|:|||..||.:
Mouse   128 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNE--CEITKRRRKSCQACRFMKCLK 190

  Fly    99 VGMNKDAVQHE--RGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGL 161
            |||.|:.|:.:  ||.|....||                 |.||            ..|...|.|
Mouse   191 VGMLKEGVRLDRVRGGRQKYKRR-----------------IDAE------------NSPYLNPQL 226

  Fly   162 PQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALP-PTPP 225
            .|.|                         :.|::.: ..|.....|...|       |:| ||.|
Mouse   227 VQPA-------------------------KKPYNKI-VSHLLVAEPEKIY-------AMPDPTVP 258

  Fly   226 ---LMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFA 287
               :.|...:.:.|...|...:.|.|.:..|:.|.:.||:.||:.:|.|..||.:.  ...::|.
Mouse   259 DSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVV--YRSLSFE 321

  Fly   288 -QLLFV--YESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASST 349
             :|::.  |..:....::.|::... :|..:::.:...:.::..|:..|:||:|
Mouse   322 DELVYADDYIMDEDQSKLAGLLDLN-NAILQLVKKYKSMKLEKEEFVTLKAIAL----------- 374

  Fly   350 EDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVV 414
                              |:::|..:.:...|..:.:....||.:|....|...|.|...:|..:
Mouse   375 ------------------ANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTL 421

  Fly   415 QLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            .|:.:.|:..::..:..|..|.:.:.:|..:|
Mouse   422 PLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEM 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	35/84 (42%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	43/227 (19%)
Esrrg	NP_036065.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..85
		NR_DBD_ERR	122..218	CDD:143544	40/120 (33%)
		NR_LBD_ERR	237..456	CDD:132744	49/257 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910