DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and esr1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_009297713.1	Gene:	esr1 / 259252	ZFINID:	ZDB-GENE-020806-5	Length:	613	Species:	Danio rerio

Alignment Length:	431	Identity:	113/431 - (26%)
Similarity:	179/431 - (41%)	Gaps:	79/431 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|::||.|||:::|:||..||||||:....|||.:..|  |.:|:..|..|:|||||||:|
Zfish   196 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQ--CTIDRNRRKSCQACRLRKCYE 258

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAAL--TGFPGVPMPMPGL 161
            |||.|..::.:||.|:....|..:..:|......:.        .:.|.:  ||      |....
Zfish   259 VGMMKGGIRKDRGGRSVRRERRRSSNEDRDKSTSDQ--------CSRAGVRTTG------PQDKR 309

  Fly   162 PQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPL 226
            .:|:|...:.: ...|......:|....|.|.....|...:     |...|.:|.|
Zfish   310 KKRSGGVVSTL-CMSPDQVLLLLLGAEPPAVCSRQKHSRPY-----TEITMMSLLT--------- 359

  Fly   227 MAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLM----PMNFA 287
                   ..|.:.|...:.|.|.|..|.:|.:.||:.|||.||.|..::.:....:    .:.||
Zfish   360 -------NMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPGKLIFA 417

  Fly   288 QLLFVYESE----NANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASS 348
            |.|.:..||    ....||..|:...|..|:.       |.:...|:.||:||
Zfish   418 QDLILDRSEGECVEGMAEIFDMLLATVARFRS-------LKLKLEEFVCLKAI------------ 463

  Fly   349 TEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPS---QPMRFQTL 410
                    ||..||: .|..|:....|:::..|..|.::...||...|.::..|   |..|...|
Zfish   464 --------ILINSGA-FSFCSSPVEPLMDNFMVQCMLDNITDALIYCISKSGASLQLQSRRQAQL 519

  Fly   411 LGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRK 451
            |.::..:..:|:..:|.|:..|....:.:..|:.:|...::
Zfish   520 LLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	41/82 (50%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	55/231 (24%)
esr1	XP_009297713.1	WWbp	45..192	CDD:304964
		NR_DBD_ER	191..269	CDD:143545	38/74 (51%)
		NR_LBD_ER	322..559	CDD:132747	64/285 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910