DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and Ppara

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006242213.1	Gene:	Ppara / 25747	RGDID:	3369	Length:	605	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	121/513 - (23%)
Similarity:	183/513 - (35%)	Gaps:	158/513 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSSEGSPDMMDQKY--------NSV---RLSPAASSRIL----------------YHVPCKVCRD 39
            :.|.||....|.:|        .||   .||||:|...:                .::.|::|.|
  Rat   180 EESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGD 244

  Fly    40 HSSGKHYGIYACDGCAGFFKRSIRRSRQY-VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNK 103
            .:||.|||::||:||.|||:|:||....| .|...    |.:.|.:||:|:.||..||..|||:.
  Rat   245 KASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRS----CKIQKKNRNKCQYCRFHKCLSVGMSH 305

  Fly   104 DAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEIL--------MNTAALTGFPGVPMPMPG 160
            :|::..|.||:                  |..::.||||        ..||.|          ..
  Rat   306 NAIRFGRMPRS------------------EKAKLKAEILTCEHDLKDSETADL----------KS 342

  Fly   161 LPQRAGHHPAHMAAF-QPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNAL--ATRALPP 222
            |.:|.  |.|::..| .....|..:|.......|...:|.            |..|  |.:.|..
  Rat   343 LAKRI--HEAYLKNFNMNKVKARVILAGKTSNNPPFVIHD------------METLCMAEKTLVA 393

  Fly   223 TPPLMAAEHIKETAAEHLF-------------KNVNWIKSVRAFTELPMPDQLLLLEESWKEFFI 274
            .   |.|..::...||..|             :...:.|::..|..|.:.||:.||:....| .|
  Rat   394 K---MVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYE-AI 454

  Fly   275 LAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCH--------------LNI 325
            ..|...|  ||...:|..|.:        |.:|||.  .:.:....|.              |.:
  Rat   455 FTMLSSL--MNKDGMLIAYGN--------GFITREF--LKNLRKPFCDIMEPKFDFAMKFNALEL 507

  Fly   326 DSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARS 390
            |.::      ||||              .::|:.....|         |||..|.:..:......
  Rat   508 DDSD------ISLF--------------VAAIICCGDRP---------GLLNIGYIEKLQEGIVH 543

  Fly   391 ALHNYIQRTHPSQPMRFQTLL-GVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMY 447
            .|..::|..||.....|..|| .:|.|...|:.........:||..|..:..|:.::|
  Rat   544 VLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIY 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/108 (34%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	52/250 (21%)
Ppara	XP_006242213.1	NR_DBD_Ppar	238..321	CDD:143523	37/104 (36%)
Ppara	XP_006242213.1	NR_LBD_PPAR	338..604	CDD:132730	67/333 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910