DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and Pparg

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_037256.1	Gene:	Pparg / 25664	RGDID:	3371	Length:	505	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	109/517 - (21%)
Similarity:	177/517 - (34%)	Gaps:	172/517 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEGSPDMMDQKY--------NSVRLSPAA-----------------SSRILYHVPCKVCRDHSSG 43
            :...|.:.|.||        :::::.||:                 .|..|..:.|:||.|.:||
  Rat    84 TRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASG 148

  Fly    44 KHYGIYACDGCAGFFKRSIRRSRQY-VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQ 107
            .|||::||:||.|||:|:||....| .|...    |.:.|..||:|:.||.:||..|||:.:|::
  Rat   149 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLN----CRIHKKSRNKCQYCRFQKCLAVGMSHNAIR 209

  Fly   108 HERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHM 172
            ..|.|:                  .|..::.|||..:...|.
  Rat   210 FGRMPQ------------------AEKEKLLAEISSDIDQLN----------------------- 233

  Fly   173 AAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPP--------LMAA 229
                 |.||    ||   |.....::..:...|..|.|...|:.|.......|        ||..
  Rat   234 -----PESA----DL---RALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286

  Fly   230 E------HI-------KETAAEHL----FKNV-------NWIKSVRAFTELPMPDQLLLLEESWK 270
            |      ||       ||.|....    |::|       .:.|::..|..|.:.||:.||:....
  Rat   287 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVH 351

  Fly   271 EFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLC----HLNIDSTEYE 331
            |.....:|..   ||...:|.........||.:..:.:....|.|...:..    .|.:|.::..
  Rat   352 EIIYTMLASL---MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLA 413

  Fly   332 CLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYI 396
            ...|:.:.                             |.:..|||....:..:.::...||...:
  Rat   414 IFIAVIIL-----------------------------SGDRPGLLNVKPIEDIQDNLLQALELQL 449

  Fly   397 QRTHPSQPMRF-----------QTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMY 447
            :..||.....|           |.:...|||:|.:          :||..|:::..|:.::|
  Rat   450 KLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVI----------KKTETDMSLHPLLQEIY 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/92 (41%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	47/267 (18%)
Pparg	NP_037256.1	PPARgamma_N	31..108	CDD:403692	4/23 (17%)
		NR_DBD_Ppar	138..221	CDD:143523	37/104 (36%)
		Interaction with FAM120B. /evidence=ECO:0000250	205..280		20/127 (16%)
		NR_LBD_PPAR	237..504	CDD:132730	58/314 (18%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P37231	495..503		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910