Protein Alignment tll and Pgr

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_074038.2
• Gene: Pgr / 25154
• RGDID: 3317
• Length: 926
• Species: Rattus norvegicus
• Alignment Length: 458
• Identity: 106/458 - (23%)
• Similarity: 172/458 - (37%)
• Gaps: 91/458 - (19%)

  Fly     9 DMMDQKY----NSVRLSPAASSRILY---HVP---CKVCRDHSSGKHYGIYACDGCAGFFKRSIR 63
            |.:.|.|    |.:|....||....|   .:|   |.:|.|.:||.|||:..|..|..||||::.
  Rat   525 DSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAME 589

  Fly    64 RSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAM 128
            ....|:|..:..  |:|||..|..|.|||||||.:.||....            |:.....|..:
  Rat   590 GQHNYLCAGRND--CIVDKIRRKNCPACRLRKCCQAGMVLGG------------RKFKKFNKVRV 640

  Fly   129 MGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVP 193
            |.|.:...:|..:           |:|.....|.||....|.......||     :::|.:...|
  Rat   641 MRALDGVALPQSV-----------GLPNESQTLGQRITFSPNQEIQLVPP-----LINLLMSIEP 689

  Fly   194 HHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPM 258
             ..|:.||......|:   ::|.|             .:.:.....|...|.|.||:..|..|.:
  Rat   690 -DVVYAGHDNTKPDTS---SSLLT-------------SLNQLGERQLLSVVKWSKSLPGFRNLHI 737

  Fly   259 PDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQ------EVL 317
            .||:.|::.||....:..:..........|:|:.......|.:.|    :|:..:.      ::.
  Rat   738 DDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRM----KELSFYSLCLTMWQIP 798

  Fly   318 NQLCHLNIDSTEYECLRAISLFRKSP----PSASSTEDLANSSI--------LTGSG-SPNSSAS 369
            .:...|.:...|:.|::.:.|....|    .|.|..|::.:|.|        |...| .|:|...
  Rat   799 QEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRF 863

  Fly   370 AESRGLLESGKVAAMHNDARSALHNYIQRT---HPSQPMRFQTLLG--VVQLMHKVSSFTIEELF 429
            .:...||:|     :| |....||.|...|   ..:..:.|..::.  :...:.|:.:..::.|.
  Rat   864 YQLTKLLDS-----LH-DLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKILAGMVKPLL 922

  Fly   430 FRK 432
            |.|
  Rat   923 FHK 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	34/97 (35%)
		NR_LBD	215..436	CDD:416257	47/242 (19%)
Pgr	NP_074038.2	Prog_receptor	1..557	CDD:396643	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		LXXL motif 1. /evidence=ECO:0000250|UniProtKB:P06401	56..60
		LXXL motif 2. /evidence=ECO:0000250|UniProtKB:P06401	116..120
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..240
		Mediates transcriptional transrepression (in isoform A). /evidence=ECO:0000250|UniProtKB:P06401	166..305
		Nuclear localization signal. /evidence=ECO:0000255	185..189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..372
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..436
		AF1, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401	453..539		4/13 (31%)
		NR_DBD_GR_PR	556..633	CDD:143546	33/90 (37%)
		NR_LBD_PR	679..926	CDD:132759	54/279 (19%)
		AF2, mediates transcriptional activation. /evidence=ECO:0000250|UniProtKB:P06401	680..926		53/273 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910