DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Esr2

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006240283.1	Gene:	Esr2 / 25149	RGDID:	2582	Length:	567	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	109/443 - (24%)
Similarity:	178/443 - (40%)	Gaps:	109/443 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|::||.|||:::|:||..||||||:....|:|.:..|  |.:||..|..|:|||||||:|
  Rat   168 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQ--CTIDKNRRKSCQACRLRKCYE 230

  Fly    99 VGMNKDAVQHE-------RGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPM 156
            |||.|...:.|       |..|:|:.:.|  ....|....|..|:: .|:|::|
  Rat   231 VGMVKCGSRRERCGYRIVRRQRSSSEQVH--CLSKAKRNGGHAPRV-KELLLST----------- 281

  Fly   157 PMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALP 221
                              ..|......:|:...|                      |.|.:|
  Rat   282 ------------------LSPEQLVLTLLEAEPP----------------------NVLVSR--- 303

  Fly   222 PTPPLMAAE---HIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAM----AQ 279
            |:.|...|.   .:.:.|.:.|...:.|.|.:..|.||.:.||:.|||..|.|..::.:    ..
  Rat   304 PSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSID 368

  Fly   280 YLMPMNFA-QLLFVYESENANREIMGMVT-------REVHAFQEVLNQLC-------HLNIDSTE 329
            :...:.|| .|:....||:.:..:..|.:       :.|....|:.:.|.       .|.:...|
  Rat   369 HPGKLIFAPDLVLDRSSEDPHWHVAQMKSAAPRDEGKCVEGILEIFDMLLATTSRFRELKLQHKE 433

  Fly   330 YECLRAISLFRKSP-PSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALH 393
            |.|::|:.|...|. |.||:.::..:|..||              .||.:...|.:...|:|.:
  Rat   434 YLCVKAMILLNSSMYPLASANQEAESSRKLT--------------HLLNAVTDALVWVIAKSGI- 483

  Fly   394 NYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
                 :...|.:|...||.::..:..:|:..:|.|...|....:.:..|:.:|
  Rat   484 -----SSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEM 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/89 (47%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	54/243 (22%)
Esr2	XP_006240283.1	ERbeta_N	35..141	CDD:289279
		NR_DBD_ER	163..244	CDD:143545	39/77 (51%)
		NR_LBD_ER	282..535	CDD:132747	60/295 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910