DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Esr1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_017444286.2	Gene:	Esr1 / 24890	RGDID:	2581	Length:	665	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	112/481 - (23%)
Similarity:	182/481 - (37%)	Gaps:	146/481 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|::||.|||:::|:||..||||||:....|:|.:..|  |.:||..|..|:|||||||:|
  Rat   223 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQ--CTIDKNRRKSCQACRLRKCYE 285

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEM--------------PQIPAEILMNTAALT 149
            |||.|..::.:|  |...:.:|... :|.:.|..||              |.:......|:.||:
  Rat   286 VGMMKGGIRKDR--RGGRMLKHKRQ-RDDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALS 347

  Fly   150 GFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRV-----PHHPVHQGHHGFFSPTA 209
                                  :.|.|   ..:|:||...|.:     |..|..:
  Rat   348 ----------------------LTADQ---MVSALLDAEPPLIYSEYDPSRPFSE---------- 377

  Fly   210 AYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFI 274
            |.|..|.|                ..|...|...:||.|.|..|.:|.:.||:.|||.:|.|..:
  Rat   378 ASMMGLLT----------------NLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILM 426

  Fly   275 LAMAQ---------------------------YLMPMNFAQLLF------VYES-ENANREIMGM 305
            :.:..                           .|:.::|::..|      .:.| .|..:.:.||
  Rat   427 IGLVWRSMEHPGKLLFAPNLLLDRDIISGLQILLVSLDFSERTFNPLTKCPFSSLRNQGKCVEGM 491

  Fly   306 VTREVHAFQEVLNQLC-------HLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGS 363
            |        |:.:.|.       .:|:...|:.||::|.|.              ||.:.|...|
  Rat   492 V--------EIFDMLLATSSRFRMMNLQGEEFVCLKSIILL--------------NSGVYTFLSS 534

  Fly   364 PNSSASAES--RGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIE 426
            ...|...:.  ..:|:......:|..|::.|      |...|..|...||.::..:..:|:..:|
  Rat   535 TLKSLEEKDHIHRVLDKITDTLIHLMAKAGL------TLQQQHRRLAQLLLILSHIRHMSNKGME 593

  Fly   427 ELFFRKTIGDITIVRLISDMYSQRKI 452
            .|:..|....:.:..|:.:|....::
  Rat   594 HLYNMKCKNVVPLYDLLLEMLDAHRL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	40/82 (49%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	51/263 (19%)
Esr1	XP_017444286.2	Oest_recep	75..219	CDD:396642
		NR_DBD_ER	218..299	CDD:143545	39/79 (49%)
		NR_LBD_ER	348..617	CDD:132747	63/325 (19%)
		ESR1_C	626..665	CDD:403830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910