DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Vdr

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_058754.2	Gene:	Vdr / 24873	RGDID:	3959	Length:	423	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	101/480 - (21%)
Similarity:	176/480 - (36%)	Gaps:	149/480 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQ 67
            :|...||..|...|..|:             |.||.|.::|.|:....|:||.|||:||::|...
  Rat     6 ASTSLPDPGDFDRNVPRI-------------CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL 57

  Fly    68 YVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAM-------YK 125
            :.|..  .|.|.:.|.:|..|:||||::|.::||.|:.:..:...:.   :|.|.|       .|
  Rat    58 FTCPF--NGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQR---KREMIMKRKEEEALK 117

  Fly   126 DAMMGAGEMPQIPAE------ILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAV 184
            |::     .|::..|      ||::                     .||..:      .|:.|..
  Rat   118 DSL-----RPKLSEEQQHIIAILLD---------------------AHHKTY------DPTYADF 150

  Fly   185 LDLSVP-RVPHHPVHQGHHGFFSP---------TAAYMNALATRAL------------------- 220
            .|...| ||      .|..|.:||         :::..:.|.|.:|
  Rat   151 RDFRPPVRV------DGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSD 209

  Fly   221 PPT-----PPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQY 280
            .|:     .||....|:.:..:..:.|.:.:.|.:..|.:|...||::||:.|..|..:|...|.
  Rat   210 DPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQS 274

  Fly   281 L----MPMNFAQLLFVYESENANR-----EIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAI 336
            .    |..:.....:.|:..:.::     |::..:.:    ||..|.:   ||:...|:..|.||
  Rat   275 FTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIK----FQVGLKK---LNLHEEEHVLLMAI 332

  Fly   337 SLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHP 401
            .:                             .|.:..|:.::..|.|:.:...:.|..||:..||
  Rat   333 CI-----------------------------VSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHP 368

  Fly   402 SQPMRFQTLLGVVQLMHKVSSFTIE 426
             .|...|....::|.:..:.|...|
  Rat   369 -PPGSHQLYAKMIQKLADLRSLNEE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	29/91 (32%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	45/245 (18%)
Vdr	NP_058754.2	NR_DBD_VDR	16..122	CDD:143513	36/128 (28%)
		Hinge	90..126		7/43 (16%)
		NR_LBD_VDR	124..422	CDD:132731	60/339 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..180		5/26 (19%)
		Vitamin D3 binding	223..233		1/9 (11%)
		Interaction with coactivator LXXLL motif	242..260		6/17 (35%)
		Vitamin D3 binding	267..274		1/6 (17%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	412..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910