DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr2e3

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_038736.1	Gene:	Nr2e3 / 23958	MGIID:	1346317	Length:	395	Species:	Mus musculus

Alignment Length:	428	Identity:	145/428 - (33%)
Similarity:	215/428 - (50%)	Gaps:	88/428 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |:||.|.|||||||||||:||:||||||:||...|.|: ...|:|.|||.|||||:||||:||.:
Mouse    40 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQ-VGAGMCPVDKAHRNQCQACRLKKCLQ 103

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLP- 162
            .|||:||||:||.||:      ||......|..|..|:  :|.::.:.||.|      |.|..|
Mouse   104 AGMNQDAVQNERQPRS------MAQVHLDAMETGSDPR--SEPVVASPALAG------PSPRGPT 154

  Fly   163 -----QRAGHH------PAHMAAFQPPPSAAAVLDLSV--PRVPHHPVHQGHHGFFSPTAAYMNA 214
                 :..|||      .|...|...|..|...:|::.  |..|..|
Mouse   155 SVSATRAMGHHFMASLITAETCAKLEPEDAEENIDVTSNDPEFPASP------------------ 201

  Fly   215 LATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQ 279
                        .:.:.|.||:|..||..|.|.|::..|:.||..||::||||:|.|.|:|...|
Mouse   202 ------------CSLDGIHETSARLLFMAVKWAKNLPVFSNLPFRDQVILLEEAWNELFLLGAIQ 254

  Fly   280 YLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPP 344
            :.:|::...||...|:..:::..:.:.:.|....||.:::...|.:|.||:.||:|:.||:
Mouse   255 WSLPLDSCPLLAPPEASGSSQGRLALASAETRFLQETISRFRALAVDPTEFACLKALVLFK---- 315

  Fly   345 SASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQT 409
                                     .|:|||.:...|.|:.:.::..|..:.:..|||||:||..
Mouse   316 -------------------------PETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGK 355

  Fly   410 LLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMY 447
            ||.::..:..:::..||.||||||||:..:.:|:.||:
Mouse   356 LLLLLPSLRFLTAERIELLFFRKTIGNTPMEKLLCDMF 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	54/82 (66%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	64/220 (29%)
Nr2e3	NP_038736.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		NR_DBD_PNR	32..123	CDD:143528	56/89 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..157		10/37 (27%)
		NR_LBD_Tlx_PNR_like	185..382	CDD:132748	68/255 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910