Protein Alignment tll and Nr1h2

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_001272446.1
• Gene: Nr1h2 / 22260
• MGIID: 1352463
• Length: 446
• Species: Mus musculus
• Alignment Length: 471
• Identity: 109/471 - (23%)
• Similarity: 182/471 - (38%)
• Gaps: 97/471 - (20%)

  Fly     4 SEGSPDMMDQKYNSVRLSP----------AASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFF 58
            ||||    ...|..|.|.|          ..:.::|.|..|:||.|.:||.||.:.:|:||.|||
Mouse    42 SEGS----SSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFF 102

  Fly    59 KRSIRR--SRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHM 121
            :||:..  :.:|.|:.  .|.|.:|...|.:|:.||||||.|.||.:..|..|...|...:::..
Mouse   103 RRSVVHGGAGRYACRG--SGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQ 165

  Fly   122 AMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLD 186
            .          :.|..|:|...:::      |.|...||..:.:..........|    ..|..:
Mouse   166 Q----------QQPPPPSEPAASSS------GRPAASPGTSEASSQGSGEGEGIQ----LTAAQE 210

  Fly   187 LSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAE------------HIKETAAEH 239
            |.:.::....:......|......            ||..:.|:            |..|.|...
Mouse   211 LMIQQLVAAQLQCNKRSFSDQPKV------------TPWPLGADPQSRDARQQRFAHFTELAIIS 263

  Fly   240 LFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMA-QYLMPMNFAQLL--FVYESENANRE 301
            :.:.|::.|.|..|.:|...||:.||:.|..|..:|..| :|.........|  |.|..::.:|
Mouse   264 VQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHR- 327

  Fly   302 IMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNS 366
             .|:....::...|....:..|.:|..||..|.||::|
Mouse   328 -AGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIF--------------------------- 364

  Fly   367 SASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFR 431
              ||:...:.|..:|.|:......||.:|.:...|...:||..:|..:..:..:||...|::|..
Mouse   365 --SADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFAL 427

  Fly   432 KTIGDITIVRLISDMY 447
            : :.|..:..|:|:::
Mouse   428 R-LQDKKLPPLLSEIW 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/93 (40%)
		NR_LBD	215..436	CDD:416257	50/235 (21%)
Nr1h2	NP_001272446.1	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250|UniProtKB:P55055	1..76		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		8/30 (27%)
		NR_DBD_like	58..154	CDD:383039	35/97 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..201		7/57 (12%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:P55055	205..446		56/282 (20%)
		NR_LBD_LXR	209..444	CDD:132752	55/278 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910