DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr1h3

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001171201.1	Gene:	Nr1h3 / 22259	MGIID:	1352462	Length:	445	Species:	Mus musculus

Alignment Length:	457	Identity:	110/457 - (24%)
Similarity:	184/457 - (40%)	Gaps:	96/457 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQY 68
            :|..|:..:.:....:..||  .::|.:..|.||.|.:||.||.:.:|:||.|||:||:.:..:|
Mouse    68 AETLPEPTELRPQKRKKGPA--PKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARY 130

  Fly    69 VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGE 133
            ||.|  .|.|.:|...|.:|:.||||||.:.||.::.|..|...|...|:|.            |
Mouse   131 VCHS--GGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ------------E 181

  Fly   134 MPQIPAEILMNTAALTGFPGVPMPMPGL-PQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPV 197
            ..|..|     |:........|..:|.| |::.|.....:||.|
Mouse   182 EEQAQA-----TSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQ--------------------- 220

  Fly   198 HQGHHGFFSPTAAYMNALATRALPPTPPLMAAE-------HIKETAAEHLFKNVNWIKSVRAFTE 255
             |.:...||      :.|.....|..|...:.|       |..|.|...:.:.|::.|.:..|.:
Mouse   221 -QCNRRSFS------DRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQ 278

  Fly   256 LPMPDQLLLLEESWKEFFILAMAQYLMP----MNFAQLLFVYESEN-ANREIMGMVTREVHAFQE 315
            |...||:.||:.|..|..:|..::...|    :.|.: .|.|..|: |...:.......:..|..
Mouse   279 LSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLK-DFSYNREDFAKAGLQVEFINPIFEFSR 342

  Fly   316 VLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGK 380
            .:|:   |.::..|:..|.|||:|                             ||:...:.:..:
Mouse   343 AMNE---LQLNDAEFALLIAISIF-----------------------------SADRPNVQDQLQ 375

  Fly   381 VAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISD 445
            |..:.:....|||.|:...||..|:.|..:|..:..:..:||...|::|..: :.|..:..|:|:
Mouse   376 VERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHSEQVFALR-LQDKKLPPLLSE 439

  Fly   446 MY 447
            ::
Mouse   440 IW 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/91 (41%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	49/232 (21%)
Nr1h3	NP_001171201.1	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250\|UniProtKB:Q13133	1..94		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..86		2/17 (12%)
		NR_DBD_LXR	76..176	CDD:143534	39/103 (38%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250\|UniProtKB:Q13133	203..445		61/301 (20%)
		NR_LBD_LXR	208..443	CDD:132752	59/296 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910