DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr2e1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_689415.1	Gene:	Nr2e1 / 21907	MGIID:	1100526	Length:	385	Species:	Mus musculus

Alignment Length:	438	Identity:	177/438 - (40%)
Similarity:	248/438 - (56%)	Gaps:	63/438 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRN 86
            ||.|:..:..:|||||.|.|||||||:||||||:|||||||||:|.|||||..||.|.|||||||
Mouse     4 PAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRN 68

  Fly    87 QCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGF 151
            |||||||:||.||.|||||||||||||.||:|:.:|:|   ..|..|          :..|...|
Mouse    69 QCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALY---FRGHKE----------DNGAAAHF 120

  Fly   152 PGVPMPMPGL---PQRAGHHPAHMAAFQPPPSAAAVLDLS--VPRVPHHPVHQGHHGFFSPTAAY 211
            |...:|.|..   ..:...|...:||....|....::.|:  .|:.||.         .:.|..|
Mouse   121 PSTALPAPAFFTAVTQLEPHGLELAAVSATPERQTLVSLAQPTPKYPHE---------VNGTPMY 176

  Fly   212 MNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILA 276
            :..:||            |.:.|:||..||.::.|.|||.||:.|.:.|||:|||::|:|.|:|.
Mouse   177 LYEVAT------------ESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLG 229

  Fly   277 MAQYLMPMNFAQLLFV--YESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLF 339
            :||:.:|::...||.|  ..::|.:.:.:..:..|:.|.|||:.:...|.:|:||:.||:.|..|
Mouse   230 IAQWAIPVDANTLLAVSGMNTDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTF 294

  Fly   340 RKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQP 404
            :..|               |.|||       |.|....:..:||:.::|:..|::||...:|:||
Mouse   295 KAVP---------------THSGS-------ELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQP 337

  Fly   405 MRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI 452
            .||..||.::..:..:|..||||:||:||||::.|.||:||||....|
Mouse   338 CRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	70/91 (77%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	75/222 (34%)
Nr2e1	NP_689415.1	NR_DBD_TLX	8..99	CDD:143537	69/90 (77%)
		NR_LBD_Tlx_PNR_like	154..369	CDD:132748	81/257 (32%)
		Required for transcriptional repression	341..385		20/43 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842652
Domainoid	1	1.000	134	1.000	Domainoid score	I5008
eggNOG	1	0.900	-	-		E33208_3BC6Q
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4525
OMA	1	1.010	-	-		QHG45707
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	1	1.000	-	-		oto91909
orthoMCL	1	0.900	-	-		OOG6_108295
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10591
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.700