DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and ESR2

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001428.1	Gene:	ESR2 / 2100	HGNCID:	3468	Length:	530	Species:	Homo sapiens

Alignment Length:	435	Identity:	112/435 - (25%)
Similarity:	174/435 - (40%)	Gaps:	111/435 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|::||.|||:::|:||..||||||:....|:|.:..|  |.:||..|..|:|||||||:|
Human   149 CAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQ--CTIDKNRRKSCQACRLRKCYE 211

  Fly    99 VGMNKDAVQHE-------RGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPM 156
            |||.|...:.|       |..|::..:.|.|  ..|....|..|:: .|:|::
Human   212 VGMVKCGSRRERCGYRLVRRQRSADEQLHCA--GKAKRSGGHAPRV-RELLLD------------ 261

  Fly   157 PMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALP 221
                             |..|......:|:...|.|                      |.:|
Human   262 -----------------ALSPEQLVLTLLEAEPPHV----------------------LISR--- 284

  Fly   222 PTPPLMAAE---HIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAM----AQ 279
            |:.|...|.   .:.:.|.:.|...::|.|.:..|.||.:.||:.|||..|.|..::.:    ..
Human   285 PSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSID 349

  Fly   280 YLMPMNFAQLLFVYESE----NANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFR 340
            :...:.||..|.:...|    ....||..|:......|:|       |.:...||.|::|:.|..
Human   350 HPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRE-------LKLQHKEYLCVKAMILLN 407

  Fly   341 KSP-PSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPS-- 402
            .|. |..::|:|                  |:|     |.|:|.:.|....||...|.::..|
Human   408 SSMYPLVTATQD------------------ADS-----SRKLAHLLNAVTDALVWVIAKSGISSQ 449

  Fly   403 -QPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
             |.||...||.::..:...|:..:|.|...|....:.:..|:.:|
Human   450 QQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEM 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	41/89 (46%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	57/235 (24%)
ESR2	NP_001428.1	Modulating	1..148
		ERbeta_N	16..122	CDD:289279
		NR_DBD_ER	144..225	CDD:143545	39/77 (51%)
		NR_LBD_ER	263..498	CDD:132747	63/287 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910