Protein Alignment tll and NR2F6

DIOPT Version :9

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_005225.2
• Gene: NR2F6 / 2063
• HGNCID: 7977
• Length: 404
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 138/431 - (32%)
• Similarity: 197/431 - (45%)
• Gaps: 91/431 - (21%)

  Fly    22 PAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRN 86
            |....|....|.|.||.|.|||||||::.|:||..||||||||:..|.|:|.:.  |.:|:.|||
Human    44 PGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRD--CQIDQHHRN 106

  Fly    87 QCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTG- 150
            ||:.|||:|||.|||.|:|||..|.|.:         ...|:..:...|  |...|  .|..:|
Human   107 QCQYCRLKKCFRVGMRKEAVQRGRIPHS---------LPGAVAASSGSP--PGSAL--AAVASGG 158

  Fly   151 --FPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMN 213
              |||.|:         ....|.:...:|.|:||                 |..|.....|.
Human   159 DLFPGQPV---------SELIAQLLRAEPYPAAA-----------------GRFGAGGGAAG--- 194

  Fly   214 ALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMA 278
                       .::..:::.|.||..||..|.|.:....|.|||:.||:.||..||.|.|:|..|
Human   195 -----------AVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAA 248

  Fly   279 QYLMPMNFAQLLF---VYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFR 340
            |..:|::.|.||.   ::.:..|....:..:. :|.||||.:::|..|.:||.||.||:||:||
Human   249 QAALPLHTAPLLAAAGLHAAPMAAERAVAFMD-QVRAFQEQVDKLGRLQVDSAEYGCLKAIALF- 311

  Fly   341 KSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPM 405
                                        :.::.||.:...|.::...|:.||..|::..:||||.
Human   312 ----------------------------TPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQ 348

  Fly   406 RFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            ||..||..:..:..|.:..|.:|||.:.:|...|..||.||
Human   349 RFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDM 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	49/91 (54%)
		NR_LBD	215..436	CDD:416257	64/223 (29%)
NR2F6	NP_005225.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		1/4 (25%)
		NR_DBD_COUP_TF	56..128	CDD:143516	44/73 (60%)
		NR_LBD_COUP-TF	165..400	CDD:132746	79/295 (27%)
		Important for dimerization. /evidence=ECO:0000250	327..404		23/63 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910