DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Rxrg

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_033133.1	Gene:	Rxrg / 20183	MGIID:	98216	Length:	463	Species:	Mus musculus

Alignment Length:	456	Identity:	117/456 - (25%)
Similarity:	190/456 - (41%)	Gaps:	116/456 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSSE------GSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFK 59
            :.|||      |.|.:.:..|.|.  ||.:   ::.|: |.:|.|.|||||||:|:|:||.||||
Mouse   106 VSSSEDIKPLPGLPGIGNMNYPST--SPGS---LVKHI-CAICGDRSSGKHYGVYSCEGCKGFFK 164

  Fly    60 RSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMY 124
            |:||:...|.|:..|.  |::||..||:|:.||.:||..:||.::|||.||      .|......
Mouse   165 RTIRKDLIYTCRDNKD--CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEER------QRSRERAE 221

  Fly   125 KDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSV 189
            .:|...:.....:|.|.::.                         |.:|.   .|...:..|::|
Mouse   222 SEAECASSSHEDMPVERILE-------------------------AELAV---EPKTESYGDMNV 258

  Fly   190 PRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFT 254
            ....:.||                                .:|...|.:.||..|.|.|.:..|:
Mouse   259 ENSTNDPV--------------------------------TNICHAADKQLFTLVEWAKRIPHFS 291

  Fly   255 ELPMPDQLLLLEESWKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREVHAFQE 315
            :|.:.||::||...|.|..|.:.:...:.:.    .|..|.|:.| :|:...:|.:...|  ..|
Mouse   292 DLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRS-SAHSAGVGSIFDRV--LTE 353

  Fly   316 VLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGK 380
            :::::..:.:|.:|..|||||.||                             :.:::||....:
Mouse   354 LVSKMKDMQMDKSELGCLRAIVLF-----------------------------NPDAKGLSNPSE 389

  Fly   381 VAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISD 445
            |..:.....:.|..|.::.:|.||.||..||..:..:..:....:|.|||.|.|||..|...:.:
Mouse   390 VETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLME 454

  Fly   446 M 446
            |
Mouse   455 M 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/91 (46%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	51/224 (23%)
Rxrg	NP_033133.1	Modulating. /evidence=ECO:0000250	1..138		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..53
		Nuc_recep-AF1	25..133	CDD:288658	9/28 (32%)
		NR_DBD_RXR	137..213	CDD:143514	40/78 (51%)
		Hinge	205..230		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..232		4/26 (15%)
		NR_LBD_RXR_like	233..441	CDD:132741	58/299 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910