DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Rxra

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_035435.1	Gene:	Rxra / 20181	MGIID:	98214	Length:	467	Species:	Mus musculus

Alignment Length:	442	Identity:	119/442 - (26%)
Similarity:	182/442 - (41%)	Gaps:	112/442 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NSVRLSPAASS----RILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQG 76
            |.|...||..|    ....|: |.:|.|.|||||||:|:|:||.|||||::|:...|.|:..|.
Mouse   119 NGVLKVPAHPSGNMASFTKHI-CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD- 181

  Fly    77 LCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHER---GPRNSTLRRHMAMYKDAMMGAGEMPQIP 138
             |::||..||:|:.||.:||..:||.::|||.||   ..||.
Mouse   182 -CLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNE----------------------- 222

  Fly   139 AEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHG 203
                 |....|......||:                       ..:|:..:...|
Mouse   223 -----NEVESTSSANEDMPV-----------------------EKILEAELAVEP---------- 249

  Fly   204 FFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEES 268
               .|..|:.  |...|.|:.|.....:|.:.|.:.||..|.|.|.:..|:|||:.||::||...
Mouse   250 ---KTETYVE--ANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAG 309

  Fly   269 WKEFFILAMAQYLMPMN----FAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTE 329
            |.|..|.:.:...:.:.    .|..|.|:.: :|:...:|.:...|  ..|:::::..:.:|.||
Mouse   310 WNELLIASFSHRSIAVKDGILLATGLHVHRN-SAHSAGVGAIFDRV--LTELVSKMRDMQMDKTE 371

  Fly   330 YECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHN 394
            ..|||||.||                             :.:|:||....:|.|:.....::|..
Mouse   372 LGCLRAIVLF-----------------------------NPDSKGLSNPAEVEALREKVYASLEA 407

  Fly   395 YIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            |.:..:|.||.||..||..:..:..:....:|.|||.|.|||..|...:.:|
Mouse   408 YCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEM 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/98 (45%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	59/224 (26%)
Rxra	NP_035435.1	Modulating domain. /evidence=ECO:0000250	1..139		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112
		Nuc_recep-AF1	18..131	CDD:288658	5/11 (45%)
		NR_DBD_RXR	138..214	CDD:143514	39/78 (50%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P19793	165..170		2/4 (50%)
		Hinge	206..229		8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		7/49 (14%)
		NR_LBD_RXR_like	234..445	CDD:132741	63/280 (23%)
		Required for nuclear export. /evidence=ECO:0000250\|UniProtKB:P19793	353..373		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910