DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nhr-41

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_500073.3	Gene:	nhr-41 / 190865	WormBaseID:	WBGene00022423	Length:	615	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	126/480 - (26%)
Similarity:	193/480 - (40%)	Gaps:	125/480 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|.:||:|||..:|:||.||||||||:...|||:|||.  |.|.|.|||:|:.||||||..
Worm   152 CVVCGDKASGRHYGAVSCEGCKGFFKRSIRKRIGYVCRSQKD--CPVTKFHRNRCQYCRLRKCLS 214

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAAL---TGFPGV-PMPMP 159
            :||..::||.||.|.|::   .|....|..........:...:|::...|   |...|: .:..|
Worm   215 MGMRSESVQAERRPVNNS---SMLCNNDNNQQNTTPEHLSPNLLLSLVKLEHETKLGGLEALIKP 276

  Fly   160 GLP--------------QRAGHHPAHMAAFQPP---PSAAAV--------------------LDL 187
            |.|              :..|.....:....||   |:::.|                    .::
Worm   277 GSPVMLQNTQDYMDVKRESIGEDEMTVIGLVPPSASPTSSGVGSSSSISDDSGPIYTSERARFEI 341

  Fly   188 SVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRA 252
            |||....:|  :.|.        |::.:.||.                    ||..|:::|..|
Worm   342 SVPLNTQNP--RNHQ--------YISEITTRL--------------------LFLTVHFVKDSR- 375

  Fly   253 FTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESEN-ANREIMGMVTREVHA--FQ 314
             ..|.......||:..|.:.:|||:.|....:...|||     :| .|:..|||...:..|  |:
Worm   376 -VSLRTSTMEGLLKSKWCDLYILALMQTADKIKLGQLL-----DNLTNQMAMGMECGQYSAEKFE 434

  Fly   315 EVLNQLCHL----------NIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSAS 369
            ::..|:..|          .:.:.||..|:.||.         :.:||.:|.....:.|.|..||
Worm   435 KISEQMQRLLQLSQLFASRELTAVEYAYLKMISF---------TAQDLPSSMASPETRSVNQMAS 490

  Fly   370 AESRGLLESGKVAAMH--------NDARSALHNYIQRTHPSQPM--------RFQTLLGVVQLMH 418
            .|....:.|.|....|        :|:.|..::    ||.:...        ||..:|.::..:.
Worm   491 QELFEYVSSSKSTQNHMSNEHINVDDSTSEDND----THVTSQQSSVNIAAERFSRILQLLPCLR 551

  Fly   419 KVSSFTIEELFFRKTIGDITIVRLI 443
            .....||.|:||...||.::|..:|
Worm   552 WFDPATIVEIFFSGLIGPMSIETII 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	47/82 (57%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	56/249 (22%)
nhr-41	NP_500073.3	Amelogenin	<6..105	CDD:197891
		NR_DBD_TR2_like	147..233	CDD:143525	47/85 (55%)
		NR_LBD	339..582	CDD:386099	65/288 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910