DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and daf-12

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001024547.1	Gene:	daf-12 / 181263	WormBaseID:	WBGene00000908	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	406	Identity:	95/406 - (23%)
Similarity:	149/406 - (36%)	Gaps:	111/406 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GSPD--MMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQY 68
            ||||  ::|....|.|....          |:||.||::|.::.:..|:.|..||:|:..|.:::
Worm    98 GSPDDGLLDSSEESRRRQKT----------CRVCGDHATGYNFNVITCESCKAFFRRNALRPKEF 152

  Fly    69 VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHE---RGPRNSTLRRHMAMYKDAMMG 130
            .|...:.  |.::...|..|:.|||||||.|||.|:.:.:|   |..:||.|.......|.:..|
Worm   153 KCPYSED--CEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRKNSRLNNTGTCNKRSQPG 215

  Fly   131 AGEMPQIPAEILMNTAALTGFPGVPM--PMPGLP-------QRAGHH-----PAHMAAF------ 175
            ..:.||.|.:   ........|||.:  |.|..|       .:..||     |..|...
Worm   216 NQQSPQGPNQ---QPHLSPHHPGVAIYPPQPQRPLTINPMDNQMMHHMQANRPNAMPQLISPPGA 277

  Fly   176 QPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHL 240
            ||.|..:.|...:....|:..:...|:|..||.....|.:|.||.||
Worm   278 QPYPLTSPVGSSASDSPPNRSLTMMHNGEKSPDGYDPNIMAHRAPPP------------------ 324

  Fly   241 FKNVNWIKSVRAFTELPMPD--QLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIM 303
                       :|...|..|  |::|..|.:|                 |||    |.....::.
Worm   325 -----------SFNNRPKMDSGQVVLSTEEYK-----------------QLL----SRIPGAQVP 357

  Fly   304 GMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSA 368
            |::..|     |.:|:       ...|.|.........:||.::...|::.|       ..||::
Worm   358 GLMNEE-----EPINK-------RAAYNCNGHPMPAETTPPYSAPMSDMSLS-------RHNSTS 403

  Fly   369 SAESRGLLESGKVAAM 384
            |...:..:....|:|:
Worm   404 SGTEKNHMTHSTVSAI 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	31/94 (33%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	31/172 (18%)
daf-12	NP_001024547.1	NR_DBD_CAR	116..209	CDD:143524	32/104 (31%)
daf-12	NP_001024547.1	NR_LBD_F1	548..733	CDD:132727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910