Protein Alignment tll and nhr-116

DIOPT Version :10

• Sequence 1: NP_524596.1
• Gene: tll / 43656
• FlyBaseID: FBgn0003720
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_507273.2
• Gene: nhr-116 / 180129
• WormBaseID: WBGene00003706
• Length: 448
• Species: Caenorhabditis elegans
• Alignment Length: 508
• Identity: 109/508 - (21%)
• Similarity: 172/508 - (33%)
• Gaps: 164/508 - (32%)

  Fly    20 LSPAA---------------SSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYV 69
            |||.|               .||:.....|.||...:.|.||.:.:|:||..||:|.....|.:.
 Worm    21 LSPPALSAEPSTSSPSKKSIGSRVERPTECLVCGRSAHGYHYNVASCNGCKTFFRRMCLSGRSFS 85

  Fly    70 CKSQKQGLCVVDKTHRN---QCRACRLRKCFEVGMNKDAVQ-HERGPRNST----LRR------- 119
            ||..:.  | .|.|.|.   :||||||::|..|||:..|:: .|:...:||    |:|
 Worm    86 CKLDRD--C-FDLTKRKTPAKCRACRLQRCLSVGMDPGAMEVDEKAASSSTYKSLLKRSKVKEED 147

  Fly   120 --------------------------------HMAMYKDAMMGA----------GEMPQIPAEIL 142
                                            .|.:|.::.:..          .||..:  |.|
 Worm   148 QDDCQIIALVSNNSKKPWELVKSLENKLQNTIDMLVYLESKVEKFRKSSYNPDWNEMDGL--EFL 210

  Fly   143 MNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSP 207
            :.|.:..||.....||...|.|:.....      |||             ||            |
 Worm   211 LKTESRIGFADRYGPMKECPIRSDQKKL------PPP-------------PH------------P 244

  Fly   208 TAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEF 272
            ::|....      |...|     ..|:....:||..|.:.|:...|..|...|:.:|.    |..
 Worm   245 SSAKFGG------PKHNP-----DRKQWMYFNLFTTVEYAKTFMFFHRLDSRDKFILT----KHI 294

  Fly   273 FILAMAQYLMPMNFAQLLFVYESE-NANREIMGMVTR-EVHAFQEVLN--QLCHLNIDSTEYECL 333
            .:..|..:|..::.|:     :|| ..|.:.....:| :.|...:.::  .|....|...||..|
 Worm   295 TLSCMNLHLSYISVAR-----KSEVLTNPDGTSFPSRTQAHYTSKTMSVAPLIRYQIQYIEYTLL 354

  Fly   334 RAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQR 398
            :||.              |.|.::      |:.|..|:.....|..|.|       .||.:|..|
 Worm   355 KAIC--------------LCNPAV------PDLSHHAQEILSKEREKYA-------DALFDYCLR 392

  Fly   399 THPSQPMRFQTLLGVVQLMHKVSSF--TIEELFFRKTIG---DITIVRLISDM 446
            |....|..|..|:.:..::.:....  .:..|:...|:.   ...::|:|.|:
 Worm   393 TRNDGPSHFAQLMQIFDVLERQQKLQKDLHLLYILPTLAHAPKCLVIRVIEDI 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	35/99 (35%)
		NR_LBD	215..436	CDD:472173	45/229 (20%)
nhr-116	NP_507273.2	ZnF_C4	50..119	CDD:197701	29/71 (41%)
		HOLI	262..414	CDD:214658	40/187 (21%)