DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nhr-47

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_504455.1	Gene:	nhr-47 / 178933	WormBaseID:	WBGene00003637	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	90/439 - (20%)
Similarity:	152/439 - (34%)	Gaps:	152/439 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|.::||||.:.:|:||..||:|::..:|::||:..|.  |.|:|..|..||.|||:||..
Worm    11 CAVCDDIATGKHYSVASCNGCKTFFRRALVNNREFVCQGNKD--CPVNKGVRCACRYCRLQKCLA 73

  Fly    99 VGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQ 163
            |||:|:::|::|.....|.|:.  .:.|..|..|.
Worm    74 VGMDKNSIQNDRDRIGYTKRKR--RHDDNDMEGGV------------------------------ 106

  Fly   164 RAGHHPAHM---AAFQP-----PPSAAAVLDLSV------PRVPHHPVHQGHHGFFSPTAAYMNA 214
               ||..|:   ::..|     .|.:..:.|:.:      |........:.:........|.:::
Worm   107 ---HHSEHIRDGSSGSPQMNDESPESMDMKDIKIDLNCLDPIADRLTTLENNFTLLLSRCADLHS 168

  Fly   215 LATRALPPTPPLMAAEHIK-ETAAEHLFKN----------------VNWIKSVRAFTELPMPDQL 262
            .||.......|....:.|. |.:...:..|                ::|.|:...|..||..|::
Worm   169 YATLEDALNAPSRFMQPISCEWSDNVVLTNRDDKLPFWRQRLIALYIDWAKTFSTFRSLPYADKV 233

  Fly   263 LLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDS 327
            .::......|.|:..|                          ..|.|            |:..|
Worm   234 AMVTNHASSFMIMCEA--------------------------FRTPE------------HMKSD- 259

  Fly   328 TEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSAL 392
                      :.||.|       ||.| .:.:.|||..|..|:.:..|:.:|:  .:|:|..:.|
Worm   260 ----------VVRKRP-------DLPN-IVTSNSGSGCSRVSSVAGSLVSNGE--DVHDDLTNLL 304

  Fly   393 H-------------------------NYIQRTHPSQPMRFQTLLGVVQL 416
            |                         |...|....:|:...:..|::||
Worm   305 HAACIQQSINKGIMFGENSSDDKILLNLPIREIKKEPLEVPSTEGMIQL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	35/82 (43%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	42/244 (17%)
nhr-47	NP_504455.1	NR_DBD_HNF4A	11..86	CDD:143518	34/76 (45%)
nhr-47	NP_504455.1	HOLI	<423..523	CDD:214658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910