DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nhr-100

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_501731.1	Gene:	nhr-100 / 177806	WormBaseID:	WBGene00003690	Length:	437	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	87/383 - (22%)
Similarity:	152/383 - (39%)	Gaps:	120/383 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MDQKYNSVRLSPAASSRILYHVP-------CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQY 68
            |:..:|||       |:|.:..|       |.||.|....:|||..:|:||.|||:|||...|.|
Worm     1 MNIPFNSV-------SKIQWRNPSPVSDTSCLVCGDPHGKRHYGAMSCNGCKGFFRRSIWEKRTY 58

  Fly    69 VCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNST---------LRRHMAMY 124
            .|....:  |:::..:||:||||||::|..|||:.:||:.||..:..|         ::...|..
Worm    59 KCSFNNE--CIIEFKYRNRCRACRLKRCLHVGMDANAVRSERTRKIKTEIDGDVKLEIKEEPADS 121

  Fly   125 KDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSV 189
            :||      ..:.|.:|.         |.:.|                 |:|.....|.:| ...
Worm   122 EDA------DDECPLDIK---------PDIAM-----------------AWQTKEIIAHML-YEE 153

  Fly   190 PRV-----PHHPVHQGHHGFFSPTAAYMNAL--ATRALPPTP--------PLMAAEHIKETAAEH 239
            .||     |::.:.     :::..:..:.|:  .::....|.        ||:..|.::......
Worm   154 DRVLNWEEPYNKLR-----YYTMDSEVLQAIKDPSQVCARTKINWNSHSRPLITIEALRFNWCRT 213

  Fly   240 LFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYES--------- 295
            ....::|.:::..:..|...|:.||::.|            |||:.:  |.:.|:|
Worm   214 FTLTIDWFETLPEYRALIDDDKELLVKFS------------LMPVGW--LWYAYKSYEYRCDGIV 264

  Fly   296 ----------ENANREI-------MGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAI 336
                      :...:::       .|.:|....|  :|:|.:..|.:|.||...|:||
Worm   265 FVDGSWFPRDKTIQQQVCPTCVLYYGRITESFMA--DVVNSMKELEMDETEMVLLKAI 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	40/107 (37%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	28/158 (18%)
nhr-100	NP_501731.1	NR_DBD_HNF4A	24..98	CDD:143518	34/75 (45%)
nhr-100	NP_501731.1	HOLI	210..376	CDD:214658	24/127 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910