DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nhr-46

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001023065.1	Gene:	nhr-46 / 177350	WormBaseID:	WBGene00003636	Length:	576	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	104/508 - (20%)
Similarity:	184/508 - (36%)	Gaps:	129/508 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSSEGSPDMMDQKYNSVRLSPAASSR-----ILYHVPCKVCRDHSSGK-HYGIYACDGCAGFFKR 60
            ::.|...:.|..|.::::......||     ::....|..|...|:.: |||..:|.||..||:|
Worm   109 ENGETGRNFMTMKQDALQAITNTVSRNSPPNVIKGERCVGCGSESAIRVHYGASSCHGCKAFFRR 173

  Fly    61 SIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERG-----PRNSTLRRH 120
            |:...|.|:|.:...  |.:....||:|||||||.|.|.|||...|:.||.     |.|:.....
Worm   174 SVFEGRVYMCSADNH--CDITNESRNRCRACRLRNCLEGGMNPKHVREERSKIERMPGNTCTVSA 236

  Fly   121 MAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVL 185
            ......:...|...|:......::|.|       |....| ...:|..||.:.:.....|.|.||
Worm   237 ANGVSHSSSAASASPEHKFSFSLSTIA-------PSTSTG-SFSSGSQPAPIESTNSSGSEAEVL 293

  Fly   186 DLSVPRVPHHPVHQGHHGFFSPTAAYMNALATR-------------------------------- 218
            |..:.:.             :....:|.||..:
Worm   294 DRKLIQE-------------NQLTLFMVALEKQTEQLTDDDVKDNDVMGAWSRDITLTFGLQHPQ 345

  Fly   219 -ALPPTPPLMAAEHIKETAAEHL--FKN----VNWIKSVRAFTELPMPDQLLLLEESWKEFFILA 276
             .:...|...:.:.|.|.|..:|  :::    .:|...:..|..||:.||..|.::::..|..:.
Worm   346 MVIKRLPLKYSCDRIMEAADLYLSWYRSFVFAADWAMGIPEFRVLPLADQTTLFKQNFMAFGWIT 410

  Fly   277 MA-------QYLMPMNFAQLLFV-YESENANR------EIMGMVTREVHAFQEVLNQLCHLNIDS 327
            .|       |:|..|......:: |..|:..:      :..|:|.|::  ...::..:..|.|..
Worm   411 FAYKCFELKQHLTGMPLGNGAYIPYNDEDQKKLPERWAQTYGVVCRKL--IDLIVKAMIELQITE 473

  Fly   328 TEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSAL 392
            .||..::.||||::             ..||:.:|               .|..:.|.:....||
Worm   474 EEYCLIKTISLFQQ-------------DCILSEAG---------------QGICSRMRDRLLDAL 510

  Fly   393 HNYIQRTHP--------SQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDI 437
            ..:|::.:|        ::.::...:|.....:.:|.|..|.:|    |..|:
Worm   511 SAHIEKRYPYHTTSQRMTRALKISLMLPSFSHIGQVESTLITQL----TAADL 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	38/102 (37%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	46/281 (16%)
nhr-46	NP_001023065.1	ZnF_C4	146..215	CDD:197701	31/70 (44%)
nhr-46	NP_001023065.1	NR_LBD	365..540	CDD:132726	36/204 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910