DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nhr-6

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_497731.1	Gene:	nhr-6 / 175462	WormBaseID:	WBGene00003605	Length:	619	Species:	Caenorhabditis elegans

Alignment Length:	366	Identity:	86/366 - (23%)
Similarity:	131/366 - (35%)	Gaps:	119/366 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFE 98
            |.||.|.:...|||...|:||.|||||:::::.:|.|...|  .|.:||.:|::|:.||.:||.|
Worm   268 CAVCNDRAVCLHYGARTCEGCKGFFKRTVQKNSKYTCAGNK--TCPIDKRYRSRCQYCRYQKCLE 330

  Fly    99 VGMNKDAVQH-----ERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPM 158
            |||.|:.|:|     .||..:|  :..:|..:|.                        |..|:|:
Worm   331 VGMVKEIVRHGSLSGRRGRLSS--KTKLARSEDQ------------------------PSPPLPL 369

  Fly   159 PGLPQRAGHHPAHMAA---FQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRAL 220
            ..|..:|.....:|..   |..|......|     |:.|..:|                 ||:.|
Worm   370 LALMGKAIEDHTNMTVVRQFMQPFDETIAL-----RILHGELH-----------------ATKKL 412

  Fly   221 PPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMN 285
                 |||...|.|..                    |...|:||.    :.||.:...:......
Worm   413 -----LMAMPQISEIQ--------------------PADFQILLS----RSFFAIMAIRVANRCG 448

  Fly   286 FAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTE-YECL-----RAISLFRKSPP 344
            .:....::||    .|:..:     :||.....|:....:|... :..|     :|.:.|.....
Worm   449 NSTDTIMFES----GELFSL-----NAFPACFQQIIRFMVDKARTFSSLVDWEPQAFAAFIALQF 504

  Fly   345 SASSTE------------DLANSSILTG-----SGSPNSSA 368
            .|.:||            |...|:|:..     |||.|..|
Worm   505 LAGNTEHNVLGLTNKPLVDQVQSTIINALKDHCSGSQNKLA 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	37/87 (43%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	35/177 (20%)
nhr-6	NP_497731.1	Pax2_C	165..261	CDD:289189
		NR_DBD_NGFI-B	266..340	CDD:143527	33/73 (45%)
		HOLI	405..560	CDD:214658	36/196 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910