DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nhr-80

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_871630.1	Gene:	nhr-80 / 175167	WormBaseID:	WBGene00003670	Length:	504	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	97/512 - (18%)
Similarity:	177/512 - (34%)	Gaps:	158/512 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRN 86
            ||:||    ...|.:|...::|.|:...:|..||.||:|::..::.:.|.:.:.. |.|..:...
Worm    22 PASSS----STRCLICSAQATGFHFEAQSCSACAAFFRRTVALTKSFKCITGRDD-CNVHYSMHQ 81

  Fly    87 QCRACRLRKCFEVGMNKDAVQHERGPR---------NSTLRRHMAMYKDAMMGAGE--------- 133
            .||:||.:||...||....||.:: |.         .|.|:|:......:...|.|
Worm    82 ICRSCRHKKCLSNGMKPGGVQPKK-PNIETGRAFFTKSGLKRNKKFANVSPQTADEQKLVVEGVK 145

  Fly   134 MPQI-----------------------PAEILMNT---AALTGFPGVPMPMPGLPQRAGHHPAHM 172
            :|:|                       |.:|..:|   |:.|.....|.|.|..|..||
Worm   146 VPKIEVQEPNSLEDLEQDNEFVIKTPTPRKISSSTSFSASTTTNYSTPGPSPMAPCSAG------ 204

  Fly   173 AAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALP----PTPPLMAAEHIK 233
                  |.   ||.|.:..  ...:.:.....||..|........:..|    ...||:..: .:
Worm   205 ------PD---VLTLFIRE--EMKLGERRRLLFSERAVGTLLGQNKHCPYKKEDIKPLVFHD-FR 257

  Fly   234 ETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENA 298
            .|...|:.....|:::.....||...|::.||.::       .:..:|:..:|..    |:....
Worm   258 LTIKTHIMLVYEWLQTWPELQELDDFDRMSLLRKA-------VLIHFLLDPSFLS----YQIGEP 311

  Fly   299 NREIM---GMVTREVH--------------------------AFQEVLNQLCHLNIDSTEYECLR 334
            ::.||   |.::...|                          ...|::..:..:.|...|:..|:
Worm   312 DKLIMQNGGFISTADHHGVGWEDETDISGENKRKYYVPIMKQITDEIMPAMEAMKITFEEFVALK 376

  Fly   335 AISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALH-NYIQR 398
            |::.|:                    .|..|.|   |::..|.:.:|    |...::|| :|::.
Worm   377 ALACFQ--------------------GGFENVS---EAKRHLITQQV----NRIMTSLHTHYLEN 414

  Fly   399 THPSQPMRFQTLL-----------GVVQLMHKVSSFTIEELFFRKTIGDITIVRLIS 444
            :......||.|::           ..||...::..|.|.:|       |..:::|::
Worm   415 SEEKIAERFGTIVLMLSNIFTAGNDFVQNHREIDIFHIWDL-------DKLVLQLLN 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	27/100 (27%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	42/265 (16%)
nhr-80	NP_871630.1	ZnF_C4	30..98	CDD:197701	21/68 (31%)
nhr-80	NP_871630.1	HOLI	261..436	CDD:214658	33/212 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910