DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr3c1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006525721.1	Gene:	Nr3c1 / 14815	MGIID:	95824	Length:	793	Species:	Mus musculus

Alignment Length:	465	Identity:	113/465 - (24%)
Similarity:	178/465 - (38%)	Gaps:	118/465 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSEG-SPDMMDQKYNSVRLSPAASSRILYHVP---CKVCRDHSSGKHYGIYACDGCAGFFKRSIR 63
            ||.| .||:.         ||.:||......|   |.||.|.:||.|||:..|..|..||||::.
Mouse   411 SSPGMRPDVS---------SPPSSSSTATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVE 466

  Fly    64 -RSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDA 127
             |...|:|..:..  |::||..|..|.|||.|||.:.|||.:|            |:.....|..
Mouse   467 GRQHNYLCAGRND--CIIDKIRRKNCPACRYRKCLQAGMNLEA------------RKTKKKIKGI 517

  Fly   128 MMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRV 192
            ......:.|..:|....|.       ||..:|                |..|:..::|::..|.|
Mouse   518 QQATAGVSQDTSENANKTI-------VPAALP----------------QLTPTLVSLLEVIEPEV 559

  Fly   193 PHHPVHQGHHGFFSPTAAY-----MNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRA 252
                ::.|:.... |.:|:     :|.|..|      .::||              |.|.|::..
Mouse   560 ----LYAGYDSSV-PDSAWRIMTTLNMLGGR------QVIAA--------------VKWAKAIPG 599

  Fly   253 FTELPMPDQLLLLEESWKEFFILAMA----QYLMP----MNFAQLLFVYESENANREIMGMVTRE 309
            |..|.:.||:.||:.||  .|::|.|    .|...    :.||..|.:    |..|..:..:..:
Mouse   600 FRNLHLDDQMTLLQYSW--MFLMAFALGWRSYRQASGNLLCFAPDLII----NEQRMTLPCMYDQ 658

  Fly   310 VHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILT-------------GS 361
            ......:..:|..|.:...||.|::.:.|....|.....:::|.:...:|             |:
Mouse   659 CKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGN 723

  Fly   362 GSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRT--HPSQPMRFQTLLG--VVQLMHKVSS 422
            .|.|.....:...||:|     || |....|.:|..:|  ..|..:.|..:|.  :...:.|.|:
Mouse   724 SSQNWQRFYQLTKLLDS-----MH-DVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSN 782

  Fly   423 FTIEELFFRK 432
            ..|::|.|.:
Mouse   783 GNIKKLLFHQ 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	36/95 (38%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	53/243 (22%)
Nr3c1	XP_006525721.1	GCR	27..418	CDD:366943	3/6 (50%)
		NR_DBD_GR_PR	433..511	CDD:143546	35/91 (38%)
		NR_LBD_GR	547..793	CDD:132761	60/283 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910