DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tll and AgaP_AGAP009002

DIOPT Version :9

Sequence 1:NP_524596.1 Gene:tll / 43656 FlyBaseID:FBgn0003720 Length:452 Species:Drosophila melanogaster
Sequence 2:XP_319750.4 Gene:AgaP_AGAP009002 / 1279961 VectorBaseID:AGAP009002 Length:639 Species:Anopheles gambiae


Alignment Length:615 Identity:129/615 - (20%)
Similarity:190/615 - (30%) Gaps:255/615 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 VPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKC 96
            :|||||.|.|||.|||:..|:||.|||:||......|.|...||  ||||:.:||:|:.|||:||
Mosquito    32 IPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQ--CVVDRVNRNRCQYCRLQKC 94

  Fly    97 FEVGMNKDAV--------------------------QHERGPRNSTL------------------ 117
            .::||::|||                          |::..|.:|..                  
Mosquito    95 LKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQNDAAPDSSVFDTQTPSSSDQLHHGYNGN 159

  Fly   118 RRHMAMYKDAM-------MGAGEMPQ------IPAEILMNTAA---------------------- 147
            ..|...|.:.:       ......||      |.|:.:.:|..                      
Mosquito   160 SSHSYTYSNEVGYSSPYGYSTSVTPQQTMGYDISADYVDSTTTYEPRSTMIDSDFISGHSEYRSP 224

  Fly   148 --LTGFP-----------GVPMPMPGLPQRAGHHPAH----------------MAAFQPPPSAAA 183
              .|..|           .:|.| |...|:...||.|                :......|:|.|
Mosquito   225 RDFTCLPVLYDLFVDSTTFLPSP-PASQQQQQQHPHHQHQQLSSAAQMVTSNGVGGLAGVPTATA 288

  Fly   184 VLDLSVPRVPHHPV------------------------HQGHHGFFSPTAAYMNALAT-----RA 219
            |:.::...|| .||                        |.....|.||:.|.....|.     |.
Mosquito   289 VVAVAATTVP-TPVTGSGAVFLGRTQKQKCFLLALPLSHYCPFEFISPSIALDGTTAARLRSHRV 352

  Fly   220 LP-----PTPP-----------------LMAAEH------IKETAAEH----------------- 239
            :|     .||.                 |::||.      ||..|..|                 
Mosquito   353 VPGRMVLRTPHRLTITITRTRRSLCSFLLLSAEGDINDVLIKTLAEAHANTNHKLEIVHEMFRKP 417

  Fly   240 -------LFKNVN----WI-----------------KSVRAFTELPMPDQLLLLEESWKEFFILA 276
                   .:||:.    |:                 |.:..|..|...||:|||:....|..|:.
Mosquito   418 QDVSRLLYYKNMTQEELWLDCAEKLTAMIQQIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVR 482

  Fly   277 MAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRK 341
            |::                      :|.:.|..|.....:|.|......||.|.:.:..|....|
Mosquito   483 MSR----------------------LMDLSTNSVLYGDIMLPQEAFYTSDSFEMKLVACIFETAK 525

  Fly   342 SPPSASSTED---LANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQ 403
            |......||.   |..|.:|..         .|..|:..:.::..:.|.:.||:...|:..|  .
Mosquito   526 SITELKLTETELALYQSLVLLW---------PERNGVRGNTEIQRLFNMSMSAIRQEIEANH--A 579

  Fly   404 PMR-----FQTLLGVVQLMHKVSSFTIEEL 428
            |::     ..|||..:....::|...:|.|
Mosquito   580 PLKGDVTVLDTLLNKIPTFRELSIMHMEAL 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tllNP_524596.1 NR_DBD_TLX 25..117 CDD:143537 44/110 (40%)
NR_LBD 215..436 CDD:416257 56/300 (19%)
AgaP_AGAP009002XP_319750.4 NR_DBD_ROR 27..121 CDD:143526 41/90 (46%)
NR_LBD_ROR_like 387..629 CDD:132737 48/256 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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