DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and Nr2f2

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_033827.2	Gene:	Nr2f2 / 11819	MGIID:	1352452	Length:	414	Species:	Mus musculus

Alignment Length:	420	Identity:	129/420 - (30%)
Similarity:	201/420 - (47%)	Gaps:	100/420 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 HVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRK 95
            |:.|.||.|.|||||||.:.|:||..|||||:||:..|.|::.:.  |.:|:.|||||:.|||:|
Mouse    76 HIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN--CPIDQHHRNQCQYCRLKK 138

  Fly    96 CFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPG 160
            |.:|||.::|||.                       |.||  |.:......|||.  |.|:
Mouse   139 CLKVGMRREAVQR-----------------------GRMP--PTQPTHGQFALTN--GDPL---- 172

  Fly   161 LPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPP 225
                  :..::::.:         :.|.:...|:            ||:.:    .::.:.|. .
Mouse   173 ------NCHSYLSGY---------ISLLLRAEPY------------PTSRF----GSQCMQPN-N 205

  Fly   226 LMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLL 290
            :|..|:|.|.||..||..|.|.:::..|.:|.:.||:.||..:|.|.|:|..||..||::.|.||
Mouse   206 IMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLL 270

  Fly   291 F---VYESE-NANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTED 351
            .   ::.|. :|:|.:..|  ..:..|||.:.:|..|::||.||.||:||.||
Mouse   271 AAAGLHASPMSADRVVAFM--DHIRIFQEQVEKLKALHVDSAEYSCLKAIVLF------------ 321

  Fly   352 LANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQL 416
                             ::::.||.:...|.::...::.||..|::..:|:||.||..||..:..
Mouse   322 -----------------TSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPS 369

  Fly   417 MHKVSSFTIEELFFRKTIGDITIVRLISDM 446
            :..|||..||:|||.:.:|...|..||.||
Mouse   370 LRTVSSSVIEQLFFVRLVGKTPIETLIRDM 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	42/85 (49%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	68/224 (30%)
Nr2f2	NP_033827.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72
		NR_DBD_COUP_TF	79..151	CDD:143516	40/73 (55%)
		Interaction with ZFPM2. /evidence=ECO:0000269\|PubMed:11382775	117..414		105/379 (28%)
		NR_LBD_COUP-TF	177..411	CDD:132746	78/280 (28%)
		Important for dimerization	337..414		24/63 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910