DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and nr2e1

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_002937209.2	Gene:	nr2e1 / 100491500	XenbaseID:	XB-GENE-483554	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	437	Identity:	176/437 - (40%)
Similarity:	249/437 - (56%)	Gaps:	60/437 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRN 86
            |..|:..:..:|||||.|.|||||||:||||||:|||||||||:|.|||||..||.|:|||||||
Frog     4 PTGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRSYVCKSGNQGGCLVDKTHRN 68

  Fly    87 QCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMY----KDAMMGAGEMPQIPAEILMNTAA 147
            |||||||:||.||.|||||||||||||.||:|:.:|:|    |:.   .|..|..|:..|   .|
Frog    69 QCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEI---NGSTPHFPSAAL---PA 127

  Fly   148 LTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYM 212
            .|.|..|....|        |...:.|....|....::.|:.| .|.:|    |....:|...|.
Frog   128 PTFFTTVSQLEP--------HNLELTAISTTPERQTLVGLAQP-TPKYP----HEVNGAPLYLYE 179

  Fly   213 NALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAM 277
                          :|.|.:.|:||..||.::.|.|||.||:.|.:.|||:|||::|:|.|:|.:
Frog   180 --------------VATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGI 230

  Fly   278 AQYLMPMNFAQLLFV--YESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFR 340
            ||:.:|::.:.||.|  ..|:|...:.:..:..|:.|.|||:::...|.:|:||:.||:.|..|:
Frog   231 AQWAIPVDASTLLAVSGMNSDNTESQKLNKIISEIQALQEVVSRFRQLRLDATEFACLKCIVTFK 295

  Fly   341 KSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPM 405
            ...|                   |:|  .:|.|....:..:||:.::|:..|::||...:|:||.
Frog   296 AGVP-------------------PHS--GSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPC 339

  Fly   406 RFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI 452
            ||..||.::..:..::..||||:||:||||::.|.||:||||....|
Frog   340 RFGKLLLLLPALRSINPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	70/91 (77%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	72/222 (32%)
nr2e1	XP_002937209.2	NR_DBD_TLX	8..99	CDD:143537	69/90 (77%)
nr2e1	XP_002937209.2	NR_LBD_Tlx_PNR_like	154..370	CDD:132748	79/255 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4903
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45707
OrthoDB	1	1.010	-	-		D373206at33208
OrthoFinder	1	1.000	-	-		FOG0001683
OrthoInspector	1	1.000	-	-		oto102220
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10591
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.060