DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tll and rargb

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001076779.1	Gene:	rargb / 100034753	ZFINID:	ZDB-GENE-070314-1	Length:	489	Species:	Danio rerio

Alignment Length:	453	Identity:	108/453 - (23%)
Similarity:	176/453 - (38%)	Gaps:	141/453 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PDMMD------------------QKYNSVRLSPAASS-----RILYHVPCKVCRDHSSGKHYGIY 49
            ||:.|                  |..:|..:.|::.|     |:  :.||.||:|.|||.|||:.
Zfish    18 PDLRDMMEKLTVFEPTIDSTVETQSTSSEEMIPSSPSPPPPPRV--YKPCFVCQDKSSGYHYGVS 80

  Fly    50 ACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRN 114
            :|:||.|||:|||:::..|.|...|.  |.::|..||:|:.|||||||||||:|:||:::|..:.
Zfish    81 SCEGCKGFFRRSIQKNMVYTCHRDKN--CQINKVTRNRCQYCRLRKCFEVGMSKEAVRNDRNKKK 143

  Fly   115 STLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPP 179
            ..::..:.:.:...: :||:     |.|:|..:                     .||...|
Zfish   144 KDVKEEVVLPESYEL-SGEL-----EELVNKVS---------------------KAHRETF---- 177

  Fly   180 SAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEH-----------IK 233
                                       |:...:....|.:        :|:|           ..
Zfish   178 ---------------------------PSLCQLGKYTTNS--------SADHRVQLDLGLWDKFS 207

  Fly   234 ETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMP----MNFAQLLFVYE 294
            |.:.:.:.|.|.:.|.:..||.|.:.||:.||:.:..:..:|.:.....|    |.|:..|.:..
Zfish   208 ELSTKCIIKIVEFAKRLPGFTSLTIADQITLLKSACLDILMLRICTRYTPEQDTMTFSDGLTLNR 272

  Fly   295 SENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILT 359
            ::..|.. .|.:|..|.||   ..||..|.:|.||...|.||.|.
Zfish   273 TQMHNAG-FGPLTDLVFAF---AGQLLPLEMDDTETGLLSAICLI-------------------- 313

  Fly   360 GSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSS 422
                     ..:...|.|..:|..:......||..|.:|..|::|..|..:|..|..:..:|:
Zfish   314 ---------CGDRMDLEEPHRVDQLQEPLLEALKIYARRRRPNKPHMFPRMLMKVTDLRGIST 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	45/96 (47%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	48/223 (22%)
rargb	NP_001076779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..57		4/19 (21%)
		NR_DBD_RAR	60..140	CDD:143522	43/83 (52%)
		NR_LBD_RAR	164..394	CDD:132735	54/297 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910