DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tll and rorc

DIOPT Version :9

Sequence 1:	NP_524596.1	Gene:	tll / 43656	FlyBaseID:	FBgn0003720	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_001344049.3	Gene:	rorc / 100004847	ZFINID:	ZDB-GENE-110411-42	Length:	480	Species:	Danio rerio

Alignment Length:	503	Identity:	113/503 - (22%)
Similarity:	188/503 - (37%)	Gaps:	130/503 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKC 96
            :|||:|.|.|||.|||:..|:||.|||:||...|.||.|  .:|..|.:|:..||:|::|||:||
Zfish     9 IPCKICGDKSSGVHYGVITCEGCKGFFRRSQSSSVQYSC--SRQSNCPIDRASRNRCQSCRLKKC 71

  Fly    97 FEVGMNKDAV---------------------QHERGPRNST-----LRRHMAMYKDAMMGAGEMP 135
            ...||::|||                     ||:|...||.     |:.:.:........:..:|
Zfish    72 VAQGMSRDAVKFGRMSKRQRDSLFAEVERHRQHQRLQANSVQEPQPLQAYRSSKDTREQPSHLIP 136

  Fly   136 QIPAEILMNT-AALTGFPGVPMP----------MPGL----PQRAGHHPAHMA--AFQPPPSA-A 182
            .:||....:. ..|.|.|...:|          ..||    |.|.|.:.:..|  .|:...|. .
Zfish   137 PLPAAYPFSVEPELAGCPAEVIPYLDCHIVEAQTQGLAYRVPLRRGENNSLSAGRGFESTRSTPE 201

  Fly   183 AVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETA----------- 236
            ::|:::...:..|| ......|||    |..:|.|..|..:   :...| |||.
Zfish   202 SILNMTGSEMGFHP-FDPESSFFS----YPTSLQTEELAAS---IIRSH-KETTQYRLEELQALR 257

  Fly   237 -------AEHLFKN---------------------VNWIKSVRAFTELPMPDQLLLLEESWKEFF 273
                   ..|::::                     |.:.|.:..|.:|...||:.||:....|..
Zfish   258 WKVFSREEVHIYQSKPVDEMWQYCAVRLSDAVQYVVEFAKRIPGFRQLCQNDQIALLKSGSMEVV 322

  Fly   274 ILAMAQYLMPMNFAQLLFVYESENANREIMGMVTRE--VHAFQEVLNQLCHLNIDSTEYECLRAI 336
            ::.|.:.   .|.|.....::.:.|..|:...:...  :.|..|..|.||.|.::..:.....|:
Zfish   323 LVRMTRM---FNTANNTVFFDGKYAGTELFKSLACSDLIAAVFEFANNLCALRLNEQQMAVFTAM 384

  Fly   337 SLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHP 401
            .|.....|.....|                             :|..:..:...||.:.:.|  .
Zfish   385 ILINPDRPCLEDRE-----------------------------RVQRVRTEVELALRHILHR--D 418

  Fly   402 SQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQ 449
            :|....|.|...|.::..:.:..||:|.:.:.:..:|:..|...:|.:
Zfish   419 NQESLLQKLYQRVPVLRSMCALHIEKLQWFRQLYPLTVHSLFPPLYKE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tll	NP_524596.1	NR_DBD_TLX	25..117	CDD:143537	44/110 (40%)
tll	NP_524596.1	NR_LBD	215..436	CDD:416257	43/261 (16%)
rorc	XP_001344049.3	NR_DBD_ROR	4..98	CDD:143526	39/90 (43%)
rorc	XP_001344049.3	NR_LBD_ROR_like	232..468	CDD:132737	44/273 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910