DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cindr and SH3PXD2A

DIOPT Version :9

Sequence 1:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001380944.1	Gene:	SH3PXD2A / 9644	HGNCID:	23664	Length:	1133	Species:	Homo sapiens

Alignment Length:	992	Identity:	195/992 - (19%)
Similarity:	329/992 - (33%)	Gaps:	235/992 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVSSNGNGT 72
            :|...|..:|..||.||.|.::..|::...|||  .:..|...|..|..::.. ::|...:.:..
Human   172 VVVSNYKKQENSELSLQAGEVVDVIEKNESGWW--FVSTSEEQGWVPATYLEA-QNGTRDDSDIN 233

  Fly    73 TGSGDHIEVGTAVQLR------------DKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFLGE 125
            |.....:.......||            ::..:...:...:..||..:.||:....|..:|.:.:
Human   234 TSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRK 298

  Fly   126 VEEGWWRGRLRSKVGVFPSNFVQHIEPSPVLASKRPPTIGATVTTSALTSKAANVANVAATATVP 190
            ..||||..|...|.|..|:::::..:..   ...|...:...|.......:.:|:.|..|:....
Human   299 NLEGWWYIRYLGKEGWAPASYLKKAKDD---LPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKE 360

  Fly   191 T------GGAVPPASTSISTSTTKQATKSRATAAAAASAPAEPAAIVSGSGAAAGGGAAAAVPML 249
            |      |...|.|...||......|:...|......:.    :.:..||.|.|......|....
Human   361 TPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTV----SRLAQGSPAVARIAPQRAQISS 421

  Fly   250 P-----PKPQRE-FCRVEFPYAPQNDD---------ELELKVDDIIAV---ISTELPDK---GWW 293
            |     |.|:|| ....:.|..|:...         |.:..:.|.|:.   ...|:.||   |||
Human   422 PNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWW 486

  Fly   294 KGEIRGKVGVFPDNFV-KMLAP--SEATAA---PPLPRPRPRTRP---GMGGTGAGSGSGIIDGV 349
            ..:|..|.|..|.::: |...|  |..|:.   |.:|.|.|.::|   ..|.|||.....
Human   487 YVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQD----- 546

  Fly   350 RTPRRTQRGGSFEFLGARMASFITTIFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSS 414
             :||:         |......:....|...:||..:.:..:: |..........|..:..||
Human   547 -SPRK---------LKYEEPEYDIPAFGFDSEPELSEEPVED-RASGERRPAQPHRPSPASS--- 597

  Fly   415 TTSVTTQQQKEQIGGSSSTTS------------KVYIKKTGSSSNSTTSSTTTASSSAG--RKES 465
                 .|:.:.::|.||...:            :.|.:.|.|:..|:..|.:..|||..  ||.|
Human   598 -----LQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNS 657

  Fly   466 FGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTK---PPGVGASVSIGQQRSSTSSATTSSA 527
                       .::|.|..:...:.|:.:|...::.|   .....:|::|.....|:||:::||.
Human   658 -----------PKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSL 711

  Fly   528 TTVATGLTSSSVSKS-------------------MENMLDEKVKSPPPPVLSKKPSVPLKK---- 569
            :..:..|...|.|.:                   :.:....|....|.|.|::..|...:|
Human   712 SKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDIS 776

  Fly   570 ------TPTGGVPMTGNLLGGKKKNTEGKLTTA----------VSHDLA---------------D 603
                  .|||  .:.|.|.|.|.:::|....||          .|.||.               :
Human   777 TLRRQLRPTG--QLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWE 839

  Fly   604 GLAASKMLSGANQLPESGAAGNVVIRRAATIAVEDTDFDRVERASILTDMRQGRVKAPKRRPPSA 668
            |.|.|.|...|.|                  .|:|::..                     .|...
Human   840 GPATSYMTCSAYQ------------------KVQDSEIS---------------------FPAGV 865

  Fly   669 AINVLGESNNNSVYVNGSGMSGSGGAGS---ASELSEDGGAGGKTSDD------NSTGEEPQLAK 724
            .:.||.:..:...||....:  .|.|.|   ..:.:|.....||..|.      .:.|:...|.|
Human   866 EVQVLEKQESGWWYVRFGEL--EGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEK 928

  Fly   725 PKPR-------EWEKKKAPWMEELKASQVTRKKTSPSVEPRGA--SVAERTSKLFAAEQAVSSNS 780
            .:.|       ...||..|.:.........:...:|:|:.|..  .||.|...:|.:.....:|.
Human   929 IERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPKDNNL 993

  Fly   781 SSITTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIM-SRSLSAAKVQTASSDEETRATRP 844
            |....:.:|...|..:        ..|..:||.:|...|.. ::...|.:..:..||......:.
Human   994 SCALRRNESLTATDGL--------RGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQR 1050

  Fly   845 NSLAIRNQRSVSPLVKS 861
            ||:.:...|. .|:.||
Human  1051 NSIPVSPVRP-KPIEKS 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	15/51 (29%)
		SH3_CD2AP-like_2	97..149	CDD:212807	14/51 (27%)
		SH3_CD2AP-like_3	258..310	CDD:212808	15/67 (22%)
SH3PXD2A	NP_001380944.1	PX_FISH	6..124	CDD:132798
		SH3_Tks5_1	170..222	CDD:213007	15/51 (29%)
		SH3_Tks5_2	269..322	CDD:213010	14/52 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..446		8/30 (27%)
		SH3_Tks5_3	451..504	CDD:213012	13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..840		71/371 (19%)
		SH3_Tks5_4	844..896	CDD:212952	14/92 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..924		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1029..1059		5/29 (17%)
		SH3_Tks5_5	1076..1132	CDD:212953
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	64	1.000	Inparanoid score	I5371
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050