DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cindr and Sh3kbp1

DIOPT Version :9

Sequence 1:	NP_001263129.1	Gene:	cindr / 43654	FlyBaseID:	FBgn0027598	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001361630.1	Gene:	Sh3kbp1 / 58194	MGIID:	1889583	Length:	709	Species:	Mus musculus

Alignment Length:	1008	Identity:	233/1008 - (23%)
Similarity:	330/1008 - (32%)	Gaps:	396/1008 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVLESGVS----- 66
            ||||::|.|:..|||.:..|.:|..|::..||||:|.:  :|..|:|||||||.::..:.
Mouse     4 AIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKKDMKKDLLS 66

  Fly    67 -----------SNGNGTTGSGDHIEVGTAVQLRDKSATSNRRCKVIYSYTQVNDDELTLAVGDVI 120
                       |:||....|      .|.::...:.....|||:|.:||...|||||.|.|||:|
Mouse    67 NKAPEKPMHDVSSGNALLSS------ETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125

  Fly   121 EFLGEVEEGWWRGRLRSKVGVFPSNFVQHIE----------------------------PSPVLA 157
            |.:||||||||.|.|..|.|:|||||::.:.                            |.|...
Mouse   126 EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHG 190

  Fly   158 SKRPPTIGATVTTSALTSKAANVANVAATATVPTGG-----AVPPASTSISTSTTKQATKSRATA 217
            :|...|...|:...|...|              |.|     ::...:.|.|......:|||....
Mouse   191 AKGKTTFEGTILYRAAPGK--------------TEGHRRYYSLRETTGSESDGGDSSSTKSEGAN 241

  Fly   218 AAAASAPAEPAAIVSGSGAAAGGGAAAAVPM-----------------------LPPKPQ----- 254
            ...|:|..:|.. |.|.|.   |......|:                       |||...
Mouse   242 GTMATAAIQPKK-VKGVGF---GDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPS 302

  Fly   255 ----------REFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEIRGKVGVFPDNFV 309
                      :::|:|.|||..||||||.:|..||:.:|:.:..|.|||:||:.|:.||||||||
Mouse   303 KTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV 367

  Fly   310 KMLAPSEATAAPPLPRPRPRTRPGMGGTGAGSGSGIIDGVRTPRRTQRGGSFEFLGARMASFITT 374
            |:| ||:.......|:..|
Mouse   368 KLL-PSDFDKEGNRPKKPP---------------------------------------------- 385

  Fly   375 IFAPINEPPSATQITQNQRKVSNTASTTSHMTTTNSSNSSTTSVTTQQQKEQIGGSSSTTSKVYI 439
                   ||||..:.|                                      |:.:|..|..|
Mouse   386 -------PPSAPVVKQ--------------------------------------GAGTTERKHEI 405

  Fly   440 KKTGSSSNSTTSSTTTASSSAGRKESFGSRDSLNDILSETGLPTGNVAAQRKSLENKNLDLTKPP 504
            ||.......|                               ||......:|...|.| |||.||
Mouse   406 KKIPPERPET-------------------------------LPNRTEEKERPEREPK-LDLQKP- 437

  Fly   505 GVGASVSIGQQRSSTSSATTSSATTVATGLTSSSVSKSMENMLDEKVKSPPPPVLSKKPSVPLKK 569
                                                         .|.:.||    |||..|
Mouse   438 ---------------------------------------------SVPAIPP----KKPRPP--- 450

  Fly   570 TPTGGVPMTGNLLGGKKKNTEGKLTTAVSHDLADG----LAASKMLSGANQLPESGAAGNVVIRR 630
             .|..:...|.|...:.:...|.||    |...|.    ||.|.:         ||.....:..|
Mouse   451 -KTNSLNRPGALPPRRPERPVGPLT----HTRGDSPKIDLAGSAL---------SGILDKDLSDR 501

  Fly   631 AATIAVEDTDFDRV-ERASILTDMRQGRVKAPKRRPPSAAINVLGESNNNSVYVNGSGMSGSGGA 694
            :..|.:|  .||.| .....|:.....|.||..|||||.::
Mouse   502 SNDIDLE--GFDSVISSTEKLSHPTTSRPKATGRRPPSQSL------------------------ 540

  Fly   695 GSASELSEDGGAGGKTSDDNSTGEEPQL-AKPKPREWEKKKAPWMEELKASQVTRKKTSPSVEPR 758
             ::|.||                 .|.: ..|.|.|                  .|:...|:..|
Mouse   541 -TSSSLS-----------------SPDIFDSPSPEE------------------DKEEHISLAHR 569

  Fly   759 GASVAERTSKLFAAEQAVSSNSSSITTKVQSSAVTSSMFVENSTTSSSVITSSSHTTTNDAIMSR 823
            |..|:::|||.....| ||.|.:|:..|..:.|..||     ...|.|.:.||.        ||.
Mouse   570 GIDVSKKTSKTVTISQ-VSDNKTSLPPKPGTMAAASS-----GPASLSSVASSP--------MSS 620

  Fly   824 SLSAAKVQTASSDEETRATRPNSLAIRNQRSVSPLVKSSNA-SSSQSQEEKPTSQLNNHQDASSS 887
            ||..|         ..||:.|:..:...:..:.|.|.|..| ...:.|..:..:.:...:|....
Mouse   621 SLGTA---------GQRASSPSLFSTEGKPKMEPAVSSQAAIEELKMQVRELRTIIETMKDQQKR 676

  Fly   888 RVAQLEQRVDKLEGLVLNQQRTIEELVNALKSE 920
            .:.||...:|:.:.:.|..|..:.::..||:|:
Mouse   677 EIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cindr	NP_001263129.1	SH3_CD2AP-like_1	6..60	CDD:212806	25/52 (48%)
		SH3_CD2AP-like_2	97..149	CDD:212807	33/51 (65%)
		SH3_CD2AP-like_3	258..310	CDD:212808	29/51 (57%)
Sh3kbp1	NP_001361630.1	SH3_CIN85_1	3..55	CDD:212985	25/52 (48%)
		SH3_CIN85_2	102..154	CDD:212988	33/51 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..242		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..309		3/19 (16%)
		SH3_CIN85_3	315..370	CDD:212990	31/54 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..485		40/293 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..650		49/221 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831442
Domainoid	1	1.000	71	1.000	Domainoid score	I9408
eggNOG	1	0.900	-	-		E1_KOG4348
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1577081at2759
OrthoFinder	1	1.000	-	-		FOG0002275
OrthoInspector	1	1.000	-	-		otm43633
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5319
SonicParanoid	1	1.000	-	-		X1165
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.840